Publications

View all Oliver TG publications in the NIH PubMed Database

Selected Publications

A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest. Tsabar M, Mock CS, Venkatachalam V, Reyes J, Karhohs KW, Oliver TG, Regev A, Jambhekar A, Lahav G. Cell Rep. 2020 Aug 4;32(5):107995. PubMed PMID: 32755587.

Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells. Ireland AS, Oliver TG. Immunity. 2020 May 19;52(5):729-731. PubMed PMID: 32433945.


MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, Conley CC, Chen OS, Guthrie MR, Soltero D, Qiao Y, Huang X, Tarapcsák S, Devarakonda S, Chalishazar MD, Gertz J, Moser JC, Marth G, Puri S, Witt BL, Spike BT, Oliver TG. Cancer Cell. 2020 Jul 13;38(1):60-78.e12. Epub 2020 May 30. PubMed Central PMCID: PMC7393942.


New Approaches to SCLC Therapy: From the Laboratory to the Clinic. Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG. J Thorac Oncol. 2020 Apr;15(4):520-540. Epub 2020 Feb 1. Review. PubMed Central PMCID: PMC7263769.


Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells. Melnikova M, Wauer US, Mendus D, Hilger RA, Oliver TG, Mercer K, Gohlke BO, Erdmann K, Niederacher D, Neubauer H, Buderath P, Wimberger P, Kuhlmann JD, Thomale J. Mol Oncol. 2020 Apr;14(4):686-703. Epub 2020 Mar 10. PubMed Central PMCID: PMC7138396.


Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer. Stewart CA, Gay CM, Xi Y, Sivajothi S, Sivakamasundari V, Fujimoto J, Bolisetty M, Hartsfield PM, Balasubramaniyan V, Chalishazar MD, Moran C, Kalhor N, Stewart J, Tran H, Swisher SG, Roth JA, Zhang J, de Groot J, Glisson B, Oliver TG, Heymach JV, Wistuba I, Robson P, Wang J, Byers LA. Nat Cancer. 2020 Feb 17. NIHMSID: NIHMS1586579.


Leveraging insights into cancer metabolism-a symposium report. Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W. Ann N Y Acad Sci. 2020 Feb;1462(1):5-13. Epub 2019 Dec 2. Review. PubMed Central PMCID: PMC7255687.


MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion. Chalishazar MD, Wait SJ, Huang F, Ireland AS, Mukhopadhyay A, Lee Y, Schuman SS, Guthrie MR, Berrett KC, Vahrenkamp JM, Hu Z, Kudla M, Modzelewska K, Wang G, Ingolia NT, Gertz J, Lum DH, Cosulich SC, Bomalaski JS, DeBerardinis RJ, Oliver TG. Clin Cancer Res. 2019 Aug 15;25(16):5107-5121. Epub 2019 Jun 4. PubMed Central PMCID: PMC6697617.


MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer. Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretić L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML. Nat Commun. 2019 Aug 2;10(1):3485. PubMed Central PMCID: PMC6677768.


Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF. Nat Rev Cancer. 2019 May;19(5):289-297. Review. PubMed Central PMCID: PMC6538259.


Partners in Crime: Neutrophil-CTC Collusion in Metastasis. Guo B, Oliver TG. Trends Immunol. 2019 Jul;40(7):556-559. Epub 2019 May 15. PubMed Central PMCID: PMC6759362.


The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG. Immunity. 2018 Oct 16;49(4):764-779.e9. PubMed Central PMCID: PMC6197489.


Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R. Nat Commun. 2018 Sep 17;9(1):3787. PubMed Central PMCID: PMC6141466.


Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ. Cell Metab. 2018 Sep 4;28(3):369-382.e5. Epub 2018 Jun 28. PubMed Central PMCID: PMC6125205.


Small cell lung cancer tumors and preclinical models display heterogeneity of meuroendocrine phenotypes. Zhang W, Girard L, Zhang YA, Haruki T, Papari-Zareei M, Stastny V, Ghayee HK, Pacak K, Oliver TG, Minna JD, Gazdar AF. Transl Lung Cancer Res. 2018 Feb;7(1):32-49. PubMed Central PMCID: PMC5835590.


Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies. Cardnell RJ, Li L, Sen T, Bara R, Tong P, Fujimoto J, Ireland AS, Guthrie MR, Bheddah S, Banerjee U, Kalu NN, Fan YH, Dylla SJ, Johnson FM, Wistuba II, Oliver TG, Heymach JV, Glisson BS, Wang J, Byers LA. Oncotarget. 2017 Sep 26;8(43):73419-73432. PubMed Central PMCID: PMC5650272.


Family matters: How MYC family oncogenes impact small cell lung cancer. Brägelmann J, Böhm S, Guthrie MR, Mollaoglu G, Oliver TG, Sos ML. Cell Cycle. 2017 Aug 18;16(16):1489-1498. Epub 2017 Jul 24. Review. PubMed Central PMCID: PMC5584863.


MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Mollaoglu G, Guthrie MR, Böhm S, Brägelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, Berrett KC, Mosbruger TL, Wang J, Kohan JL, Salama ME, Witt BL, Peifer M, Thomas RK, Gertz J, Johnson JE, Gazdar AF, Wechsler-Reya RJ, Sos ML, Oliver TG. Cancer Cell. 2017 Feb 13;31(2):270-285. PubMed Central PMCID: PMC5310991.


Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo. Terry MR, Arya R, Mukhopadhyay A, Berrett KC, Clair PM, Witt B, Salama ME, Bhutkar A, Oliver TG. Cell Death Differ. 2015 May;22(5):719-30. PubMed Central PMCID: PMC4392070.


Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer. Mukhopadhyay A, Oliver TG. Mol Cell Oncol. 2015 Apr-Jun;2(2):e969651. PubMed Central PMCID: PMC4904963.


Squamous non-small cell lung cancer as a distinct clinical entity. Oliver TG, Patel J, Akerley W. Am J Clin Oncol. 2015 Apr;38(2):220-6. Review. PubMed PMID: 25806712.


GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer. Masin M, Vazquez J, Rossi S, Groeneveld S, Samson N, Schwalie PC, Deplancke B, Frawley LE, Gouttenoire J, Moradpour D, Oliver TG, Meylan E. Cancer Metab. 2014;2:11. eCollection 2014. PubMed Central PMCID: PMC4122054.


Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver TG. Cell Rep. 2014 Jul 10;8(1):40-9. PubMed Central PMCID: PMC4410849.


Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY. Cancer Discov. 2013 Aug;3(8):908-21. PubMed Central PMCID: PMC3743121.


Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. Xue W, Meylan E, Oliver TG, Feldser DM, Winslow MM, Bronson R, Jacks T. Cancer Discov. 2011 Aug;1(3):236-47. PubMed Central PMCID: PMC3160630.


Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T. Mol Cell. 2011 Jul 8;43(1):57-71. PubMed Central PMCID: PMC3160283.


Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy. Doles J, Oliver TG, Cameron ER, Hsu G, Jacks T, Walker GC, Hemann MT. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20786-91. PubMed Central PMCID: PMC2996428.


Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, Golub T, Thomale J, Jacks T, Sweet-Cordero EA. Genes Dev. 2010 Apr 15;24(8):837-52. PubMed Central PMCID: PMC2854397.


Aurora-A kinase is essential for bipolar spindle formation and early development. Cowley DO, Rivera-Pérez JA, Schliekelman M, He YJ, Oliver TG, Lu L, O'Quinn R, Salmon ED, Magnuson T, Van Dyke T. Mol Cell Biol. 2009 Feb;29(4):1059-71. PubMed Central PMCID: PMC2643803.


Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, Salmon ED, Van Dyke T. Cancer Res. 2009 Jan 1;69(1):45-54. PubMed Central PMCID: PMC4770788.


Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2973-8. PubMed Central PMCID: PMC1815291.


Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ. Development. 2005 May;132(10):2425-39. PubMed PMID: 15843415.


Getting at the root and stem of brain tumors. Oliver TG, Wechsler-Reya RJ. Neuron. 2004 Jun 24;42(6):885-8. Review. PubMed PMID: 15207233.


Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7331-6. PubMed Central PMCID: PMC165875

Trudy Oliver

Trudy G. Oliver, BSc (Hons), PhD
Principal Investigator
Associate Professor
HCI Endowed Chair in Cancer Research
trudy.oliver@hci.utah.edu

Cancer Center Bio