Understanding Transcription Factors
The inappropriate expression of genes is a common defect across different types of cancer. Transcription factors (TF), which orchestrate gene expression patterns by interacting with specific loci throughout the genome, play a key role in the growth and development of tumors. Our research goal is to understand how transcription factors choose their genomic binding sites, how binding events lead to gene expression changes, and how the actions of transcription factors are altered in cancer.
To determine the roles that transcription factors play in gene regulation, we develop and apply experimental methods that take advantage of next-generation sequencing to create high-resolution maps of gene regulatory networks. We also utilize and create computational approaches to take full advantage of these rich genomic datasets.