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The Nuclear Control of Cell Growth and Differentiation (NC) Program provides innovative approaches to better understand the genetic and mechanistic basis of cancer development.

This program’s research focuses on the mechanisms underlying basic processes in the nucleus of cells that go awry in cancer and how they contribute to oncogenesis. 

Within that broad goal, research in the NC program is centered in three Specific Aims: 

  1. To decipher the roles of gene expression and dysregulation in cancer
  2. To define relationships between metabolic dysregulation and gene networks in cancer 
  3. To reveal altered mechanisms of DNA damage, replication, and repair in cancer 

NC Leadership

Jay Gertz, PhD

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Jared Rutter, PhD

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Program Membership

HCI Cancer Center members enjoy a variety of benefits, including eligibility for leadership roles in the Center, institutional funding opportunities, and scientific/administrative support.