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The Cell Response and Regulation (CRR) Program works to decipher cellular mechanisms of cancer biology, through transdisciplinary research, providing a foundation for new approaches to clinical issues.

The program’s research focuses on the mechanisms by which cancer cells become transformed and/or progress to the metastatic malignant state.

CRR research is centered around the following three Specific Aims:

  1. To understand cellular mechanisms underlying tumor development
  2. To uncover mechanisms and pathways mediating tumor evolution and metastasis
  3. To elucidate the complex interactions among tumor cells, immune cells, and their microenvironment

CRR Leadership

Shannon Buckley

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Sheri Holmen, PhD

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Program Membership

HCI Cancer Center members enjoy a variety of benefits, including eligibility for leadership roles in the Center, institutional funding opportunities, and scientific/administrative support.