The Zhang Lab applies 3D genomics approaches to investigate the interplay between cancer genome and epigenome. We are interested in how genetic alterations cause epigenetic and transcriptional dysregulations that promote tumorigenesis, with a long-term goal of discovering novel therapeutic targets. Our group utilizes genomics and epigenomics analyses to generate hypotheses that we test using cutting-edge CRISPR technologies. Our research uniquely spans the interface between computational and experimental biology. The research directions include:
- Identifying and characterizing recurrent noncoding genomic and epigenomic alterations in cancer.
- Investigating the function of oncogenic transcription factors in cancer, particularly in 3D genome context.