Selected Publications
Lab members are highlighted
Liu Y*, Wu Z*, Zhou J*, Ramadurai DKA, Mortenson KL, Aguilera-Jimenez E, Yan Y, Yang X, Taylor AM, Varley KE, Gertz J, Choi PS, Cherniack AD, Chen X, Bass AJ, Bailey SD#, Zhang X#. A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer. Nature Communications. 2021 Dec 8;12(1):7139.
Wu Z*, Zhou J*, Zhang X*, Zhang Z, Xie Y, Liu JB, Ho ZV, Panda A, Qiu X, Cejas P, Canadas I, Akarca FG, McFarland JM, Nagaraja, AK, Goss LB, Kesten N, Si L, Lim K, Liu Y, Zhang Y, Beak JY, Liu Y, Patil DT, Katz JP, Hai J, Bao C, Stachler M, Qi J, Ishizuka JJ, Nakagawa H, Rustgi AK, Wong KK, Meyerson M, Barbie DA, Brown M, Long H, Bass AJ. Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence. Nature Genetics. 2021 Jun;53(6):881-894.
Liu Y, Guo B, Aguilera-Jimenez E, Chu VS, Zhou J, Wu Z, Francis JM, Yang X, Choi PS, Bailey SD#, Zhang X#. Chromatin Looping Shapes KLF5-dependent Transcriptional Programs in Human Epithelial Cancers. Cancer Research. 2020 Dec 15;80(24):5464-5477
Llabata P*, Mitsuishi Y*, Choi PS, Cai D, Francis JM, Torres-Diz M, Udeshi ND, Golomb L, Wu Z, Zhou J, Svinkina T, Aguilera-Jimenez E, Liu Y, Carr SA, Sanchez-Cespedes M, Meyerson M#, Zhang X#. Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma. Molecular Cancer Research. 2020 Apr;18(4):574-584.
Zhang X, Meyerson M. Illuminating the noncoding genome in cancer. Nature Cancer. 2020 Sep;1(9):864-872.
Zhang X, Choi PS, Francis JM, Gao G, Campbell JD, Ramachandran A, Mitsuishi Y, Ha G, Shih J, Vazquez F, Tsherniak A, Taylor AM, Zhou J, Wu Z, Berger A, Giannakis M, Hahn WC, Cherniack AD, Meyerson M. Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor. Cancer Discovery. 2018 Jan;8(1):108-125.
Zhang X*, Choi PS*, Francis JM*, Imielinski M, Watanabe H, Cherniack AD, Meyerson M. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nature Genetics. 2016 Feb;48(2):176-182.
*co-first author; #co-last author
