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The words Schiffman Lab next to a stylized drawing of an elephant

Research

Lab Members

Publications

Collaborations

Working to Understand Who Develops Cancer and Why

The Schiffman Lab studies pediatric hereditary cancer syndromes, with a special interest in genetic susceptibility to childhood cancers. Our research investigates molecular changes in childhood cancers, as well as the germline genetic variation that gives rise to childhood tumors. It is our goal to find out who gets cancer and why, so that we can develop ways to better predict, prevent, and treat cancer in the clinic.

Our Approach

All of our studies include the perspective of evolutionary (Darwinian) medicine, with a focus on comparative oncology to identify universal drivers of cancer risk and development. By examining the genetics of cancer in our animal relatives alongside our own, we offer a dynamic and creative approach to translational genomics. Working with collaborators from all over the country and the world, we’re able to study cancer in people, dogs, and elephants. This transdisciplinary approach continues to yield new and exciting results.

Vector illustration of man and dog standing next to elephant

Areas of Study

p53 Studies

  • p53 and Li-Fraumeni Syndrome
  • Elephant p53

Ewing Sarcoma

  • What Is Ewing Sarcoma?
  • Genetic Predispositions for Ewing Sarcoma (Project GenESis)
  • The Genetics of Ewing Sarcoma Tumors

Cancer in the Population

Contact Us

For any and all questions, or to find out how you can get involved, please email Schiffman.Research@hci.utah.edu

Joshua Schiffman, MD

Principal Investigator

Cancer Center Bio