Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)
The purpose of this notice of funding opportunity (NOFO) is to support planning and development, including pilot or feasibility research, to improve health in Native American populations. Proposed research may address health promotion, disease prevention, treatment, recovery, or services research to inform intervention implementation and dissemination. Research with Native American populations requires engagement with tribal partners and communities to develop and/or adapt interventions and clinical trial protocols, understand intervention feasibility and acceptability, and identify and/or develop scientifically rigorous and culturally appropriate study designs and methods. Preparatory studies may fill information gaps, address unknowns, allow for strengthening of partnerships with Native American community leaders and organizations, and pilot test the feasibility of the intervention and clinical trial design, thereby improving scientific rigor and cultural appropriateness of a future efficacy, effectiveness, or implementation trial. This NOFO is part of the Intervention Research to Improve Native American Health (IRINAH) initiative, which also includes PAR-25-379, which uses the R01 Research Project Grant mechanism and PAR-25-380, which uses the R21 Exploratory/Developmental Research Grant mechanism. Research projects may address topics within the identified interests of any of the participating Institutes or Centers; projects are not limited to substance use and addiction research.
For the purposes of this NOFO, Native Americans include the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. mainland border), and Native Hawaiians. The term ‘Native Hawaiian’ means any individual any of whose ancestors were natives, prior to 1778, of the area which now comprises the State of Hawaii.
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American populations. This includes 1) etiologic research that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests interventions for health promotion, prevention, treatment, or recovery, and 3) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to identify and rigorously test culturally appropriate solutions to reduce morbidity and mortality. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. This NOFO is part of the Intervention Research to Improve Native American Health (IRINAH) initiative, which also includes NOFOs using the R21 Exploratory/Developmental Research Grant mechanism (PAR-25-380) and the R34 Clinical Trial Planning Grant mechanism (PAR-25-378). Research projects may address topics within the identified interests of any of the participating Institutes or Centers; projects are not limited to substance use and addiction research.
For the purposes of this NOFO, Native Americans include the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. mainland border), and Native Hawaiians. The term ‘Native Hawaiian’ means any individual any of whose ancestors were natives, prior to 1778, of the area which now comprises the State of Hawaii.
New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)
The New Investigator Gateway Award in T1D Research is designed to support a robust pipeline of innovative projects and talented new investigators in T1D research. In addition to providing support for preliminary research, the Gateway program provides an opportunity for new Program Directors/Principal Investigators (PD/PIs) to pursue their studies within the intellectual environment of a select number of large, ongoing collaborative research programs. Embedding awardees within an established scientific framework in each of these consortia will provide unique opportunities for New and Early Stage Investigators to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. Bringing New and Early Stage Investigators into existing collaborative research networks will also benefit the networks by providing new ideas and perspectives.
This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.
Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Clinical Trials Not Allowed)
This RFA is to support courses for skills development in cross-cutting methodologies and analytics that are needed to advance behavioral and social sciences research (BSSR) but are not well-addressed by existing educational programs widely available to the BSSR community. A definition of BSSR can be found at (https//obssr.od.nih.gov/about/bssr-definition/). Short courses supported by this RFA should develop, implement, evaluate, and disseminate education and training focused on innovative methods for BSSR. Methodological domains of focus include, but are not limited to, innovative data collection methodologies and analytic techniques, analysis and linking of big data (“Big data” in this NOFO refers to large, complex, longitudinal, and/or distributed data sets generated from administrative data systems or health systems, instruments, sensors, devices, internet transactions, email, video, click streams, and/or all other digital sources available today and in the future), or needed but underutilized designs to advance research across the translational spectrum
Proposed educational programs should be integrative, both in the transdisciplinary nature of the skills and approaches taught and in applicability across a wide range of BSSR areas. The content of the course should focus on knowledge and skills necessary for the advancement of behavioral and social sciences and/or the integration of BSSR with other areas of science and technology. Content should not be limited to specific disease applications but rather focus on generally applicable research methodologies and analytics crucial for more advanced BSSR.