Discovery Could Lessen the Severity of Lyme Disease Induced Arthritis

Apr 11, 2022 10:45 AM

Author: Doug Dollemore


deer tick
University of Utah Health scientists have detected a new genetic pathway in humans that could explain why Lyme disease, a bacterial infection transmitted by deer ticks. triggers severe arthritis in some people. Photo credit: Getty Images

Of all the creatures that bite, nibble, and gnaw on us, ticks are probably the most underrated. In survey after survey, mosquitoes, bed bugs, fleas, horse flies, bees, wasps, hornets, and lice all rank as more annoying.

Yet, these tiny relatives of spiders, mites, and scorpions are responsible for more infections transmitted to humans than any other pest, accounting for more than 75% of total U.S. vector-borne disease cases, according to the Centers for Disease Control and Prevention (CDC).

The most common of these ailments is Lyme disease, a bacterial infection transmitted by deer ticks. The CDC estimates up to 476,000 Americans are diagnosed and treated for Lyme disease each year.

Untreated, Lyme disease can trigger the onset of numerous serious conditions, including arthritis. In fact, Lyme arthritis occurs in one out of every four Lyme disease cases reported to the CDC.

Understanding how and why Lyme arthritis occurs has puzzled scientists for decades. In a step toward unraveling this mystery, University of Utah Health researchers report they have discovered a new genetic pathway that could help explain why some individuals have more severe Lyme disease arthritis than others. They say the finding, based on laboratory experiments and animal studies, could eventually lead to new and improved treatments for the condition.

Janis Weis, Ph.D.
Janis Weis, Ph.D., professor of pathology in the Division of Microbiology and Immunology at U of U Health.

“The association of severe Lyme arthritis with a heightened presence of interferon, an important regulator of the autoimmune response, suggests the genetic pathway we identified could offer important new insights into how interferon regulation impacts the onset and progression of Lyme disease and other human diseases associated with elevated interferon,” says Janis J. Weis, PhD, the study’s corresponding author and a professor of pathology in the Division of Microbiology and Immunology at U of U Health.

The study appears in PLOS Pathogens.

Previously, scientists found that interferon plays a role in the onset of Lyme arthritis. However, because of interferon’s vital role in the immune system, directly inhibiting its activity would leave the body vulnerable to a host of viral infections.

To get around this problem, Weis and Jinze Li, a graduate student in her lab, decided to take a closer look at the genetic pathways that lead to interferon production.

In studies of laboratory mouse cells, they found that Borrelia burgdorferi, the bacteria that causes Lyme disease, uses a protein called p19ARF to help regulate interferon production. They also determined that the p19ARF pathway is more active in mouse strains with severe Lyme arthritis. If this is also true in people, it could help explain why some patients with Lyme arthritis have more severe symptoms than others.

“We know that some variation in the symptoms of Lyme arthritis is caused by genetic properties of the bacteria itself,” Li says. “But this study illuminates the importance of genetic differences in the hosts.”

To test this theory, Weis and Li dampened the activity of the p19ARF genetic pathway in one set of laboratory mice while inducing elevated activity of it in other mice. The animals with elevated p19ARF genetic activity developed more severe symptoms of Lyme arthritis.

Weis says that since this pathway appears to be exclusively set in motion by bacteria, it is possible therapeutic interventions could one day relieve or prevent Lyme arthritis without disrupting interferon’s key role in preventing viral infections.

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Doug Dollemore

doug.dollemore@hsc.utah.edu

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