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NIH Funding Opportunities | August 2024

Translational Resource Centers to Build Bridges Between Substance Use Epidemiology/Etiology and Prevention Intervention Research (U24 Clinical Trials Not Allowed)

Effective translation and cross-fertilization between research disciplines are long-standing and challenging problems. The purpose of this notice of funding opportunity (NOFO) is to seek innovative applications for Translational Resource Center that will establish and support multidisciplinary research teams to conduct translational research between the fields of 1) substance use epidemiology and etiology and 2) substance use prevention intervention. Resource centers are expected to conduct activities that bring investigators in these fields together for active collaboration to develop research questions, design study approaches (with either collection of new data or analysis of existing data), and to develop strategies for application of findings from one field into research in the other field. Collaborative activities supported by the Center should have specific goals that lead to concrete products (e.g., publications, grant applications, intervention development or adaptation) and must include a plan for evaluating center success. 

Alzheimer's Clinical Trials Consortium (ACTC) Clinical Trials (R01 Clinical Trial Required)

This Notice of Funding Opportunity (NOFO) invites applications to develop and implement multi-site Phase Ib to III clinical trials of promising pharmacological and non-pharmacological interventions that may prevent, delay, or treat the symptoms of Alzheimer's disease (AD) and other age-related dementias using the Alzheimer's disease Clinical Trials Consortium (ACTC) trial coordination and management infrastructure.

Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) is intended to stimulate and support research that will use behavioral measures and computational methods to define novel clinical signatures that can be used for individual-level prediction and clinical decision making in mental disorders. A multi-component approach is proposed in which grantees will (1) identify and/or develop behavioral tasks (and other types of measures, as appropriate) that are optimized for measurement of individual differences in individuals with or at risk of developing mental disorders; (2) collect the data from novel clinical cohorts and/or identify existing datasets that include behavioral data and other data that are typically available in the clinical record; (3) derive novel clinical signatures that incorporate behavioral measures and information derived from the clinical record, and are informative for clinical purposes; and (4) partner with the existing Data Coordinating Center (DCC) (funded under previous RFA-MH-23-106), which is responsible for coordinating the harmonization of methods, aggregation of data, analysis of combined data, and creation of a data infrastructure to support data sharing with the scientific community. Applicants may propose new cohorts from one or more populations targeted to specific clinical groupings (e.g., mood/anxiety disorders, disorders of behavior regulation, psychosis) and/or care delivery settings, may leverage data from existing clinical research cohorts that have appropriate data structures, or may use a combination of approaches with new and existing data.

NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to provide salary support for exceptional Research Software Engineers (RSEs) that contribute their skills to the development and dissemination of biomedical, behavioral or health related software, tools, and algorithms as well as to the training of prospective users of these tools. 

HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies): Chronic Pain Program (UC2 Clinical Trial Optional)

As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the National Institute of Arthritis and Musculoskeletal and Skin Diseases and other participating NIH Institutes and Centers invite applications for the HEAL KIDS Chronic Pain Collaborating Research Teams (HEAL KIDS CPT) Program to conduct interdisciplinary team-based research projects that combine clinical research, novel/cutting-edge technologies, and measurement science, which will improve our understanding of primary and secondary chronic pain conditions in children and adolescents. The results are expected to enhance and expand our capacity to pursue challenging biological problems, therapeutics development, and effective management of pediatric pain conditions.
 

The HEAL KIDS CPT projects are expected to address a significant scientific challenge in the biopsychosocial model of pain that requires collaboration, synergy, knowledge integration and team interactions. Teams are encouraged to consider transformative objectives and design projects that would lead to new, innovative, and improved strategies to enhance understanding of chronic pain mechanisms at the individual level. Research may include testing of powerful tools, models, and approaches to accelerate the development and translation of pain condition-specific, age-appropriate therapeutics, and next-generation clinical management of pain. 


This Notice of Funding Opportunity (NOFO) complements the previously issued NOFO (RFA-HD-24-011) and NOFO (RFA-HD-24-012) focused on clinical trials of acute pain in infants, children, and adolescents and the establishment of a HEAL KIDS Resource Center, respectively.