All Initiative Faculty
Fred Adler, PhD
Title: Professor - Biology and Math
Mathematical modeling in virology, epidemiology and immunology, with a focus on linking across different scales of spatial and temporal organization.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: mathematical epidemiology, mathematical immunology, virology, theoretical biology
Email: adler@math.utah.edu
Krow Ampofo, MBCHB
Title: Professor - Pediatrics (Infectious Diseases)
My research focuses on the epidemiology and diagnosis of respiratory infections, and the use of metagenomic sequencing as a diagnostic and evaluation tool.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: respiratory viral infection, Influenza, epidemiology, diagnostics, antivirals
Email: Krow.Ampofo@hsc.utah.edu
Djordje Atanackovic, MD
Title: Associate Professor - Internal Medicine (Hematology/BMT)
Our goal is to develop novel immunotherapies for different types of solid tumors and hematologic malignancies with a focus on Multiple Myeloma. This includes antibody-based and cellular immunotherapies such as CAR T cells and TCR-transduced T cells. We have also developed a number of techniques for the detailed immunomonitoring of clinical trials with novel immunotherapeutic agents.
3i Bridge/Pillar: Cancer
Keywords: cancer immunotherapy, tumor immunology, CAR T cells, TCR-transduced T cells, monoclonal antibodies
Markus Babst, PhD
Title: Professor - Biology
My lab is interested in the regulation of nutrient transporters. Particularly, we focus on the post-translational regulation of transporters and study how this regulation is linked to the cell's metabolism.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: protein trafficking, metabolism, cell biology
Email: m.babst@utah.edu
Amy Barrios, PhD
Title: Professor - Medicinal Chemistry
Research in the Barrios lab focuses on developing chemical tools that can be applied to further out understanding of important biological processes such as immunological signaling. We have been working to develop a unified approach to phosphatase selective substrate and inhibitor design and providing the toolkit necessary to elucidate the biological roles of phosphatase enzymes in health and disease.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: enzymology, fluorogenic assays, cellular signaling, protein phosphatases, chemical probes
Email: amy.barrios@utah.edu
Lou Barrows, PhD
Title: Professor - Pharmacology and Toxicology
My laboratory is dedicated to the discovery of new anti-cancer and anti-infective agents. Much of what we do can be considered natural products drug discovery. We identify new drug leads based on their novel chemical structure or mechanism of action. Extracts of macro- and microorganisms from coral reefs and tropical rain forests provide the new molecules we isolate and evaluate. Determination of the molecular actions of new molecules and determination of the precise cellular consequences of their activity is often the basis of student doctoral projects. We take bioactive organisms and molecules all the way from the source to the sequencing gel, and then into animal models of human disease.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: drug discovery, natural products, antimicrobial, antineoplastic
Brenda Bass, PhD
Title: Distinguished Professor - Biochemistry
The Bass laboratory is focused on understanding the biological functions of long double-stranded RNA (dsRNA) and dsRNA binding proteins. Viruses were once thought to be the sole source of long dsRNA, but the Bass laboratory has identified numerous long dsRNAs that naturally exist in animals, primarily focusing on C. elegans and mammals. Proteins that recognize dsRNA are not sequence-specific, and the Bass laboratory is interested in how these proteins distinguish endogenous and viral dsRNA.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: dsRNA, Dicer, ADAR, antiviral
Email: bbass@biochem.utah.edu
Ellen Beswick, PhD
Title: Associate Professor - Internal Medicine (Gastroenterology)
Novel immune targets for gastrointestinal cancers.
3i Bridge/Pillar: Cancer
Keywords: colon cancer G-CSF, MK2, pancreatic cancer, PD-L1
Email: ellen.beswick@hsc.utah.edu
Srividya Bhaskara, PhD
Title: Associate Professor - Radiation Oncology and Oncological Sciences
Dr. Srividya Bhaskara performed her post-doctoral research work at Vanderbilt University. Her post-doctoral work for the first time showed unconventional functions for mammalian histone deacetylases in genome stability. Her lab at HCI focuses on elucidating mechanisms by which HDACs control genome stability and normal B-cell functions such as VDJ recombination and germinal center reactions. Her lab also performs therapeutic studies for hematological cancers such as leukemia and germinal center derived diffuse large B-cell lymphoma.
3i Bridge/Pillar: Cancer
Keywords: histone deacetylases, DNA repair, immune response, cancer therapeutics and hematopoiesis, B-lymphocyte development
Anne Blaschke, MD, PhD
Title: Professor - Pediatrics (Pediatric Infectious Disease)
Work in our laboratory is focused on better understanding the causes of invasive bacterial infections in children. We use new diagnostic technologies to better understand the pathogen-based epidemiology of infections such as pneumonia, meningitis and sepsis. In addition, we are using whole genome sequencing and comparative genomics to better understand the virulence of invasive pathogens such as Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: molecular diagnostics, pediatrics, pneumonia, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae
Email: Anne.Blaschke@hsc.utah.edu
John Bohnsack, MD
Title: Professor - Pediatrics (Allergy/Immunology)
My research focuses on identifying genetic mutations in humans that predispose to the development of autoimmune and auto-inflammatory diseases. I focus most of my efforts on Juvenile Idiopathic Arthritis in collaboration with investigators in the Utah Genome Project and other internal collaborators, and multiple extramural collaborators.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: genomics, genetics, autoimmunity, auto-inflammatory diseases, Juvenile Idiopathic Arthritis
Email: John.Bohnsack@hsc.utah.edu
Josh Bonkowsky, MD, PhD
Title: Associate Professor - Pediatrics (Pediatric Neurology)
The Bonkowsky group uses a combination of bench and clinical research approaches to understand pediatric neurological disorders.
3i Bridge/Pillar:
Keywords: pediatric, leukodystrophy, epilepsy, zebrafish, hypoxia, big data
Sihem Boudina, PhD
Title: Associate Professor - Nutrition and Integrative Physiology
My research is focused on deciphering the mechanisms underlying pathogenic fat expansion in humans and mice. As obesity is a risk factor for cardiovascular disease, we are also interested in how obesity affect cardiac metabolism.
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: autophagy, cardiac, mitochondria, adipose progenitors, redox
Email: sboudina@u2m2.utah.edu
Paul Bray, MD
Title: Professor - Internal Medicine (Hematology/BMT)
Dr. Bray’s laboratory studies the role of platelets in cardiovascular disease, and disorders of bleeding and thrombosis. He uses state-of-the-art genomic, transcriptomic and bioinformatic technologies to identify and characterize novel genes and gene variants involved in platelet reactivity. He studies the role of microRNAs in human megakaryocyte differentiation and platelet production, as well as the functional consequences of common variants that differ by geographic ancestry (“race”).
3i Bridge/Pillar: Cardiovascular
Keywords: transcriptomics, functional genomics, platelets, megakaryocytopoiesis, microRNAs
Email: paul.bray@hsc.utah.edu
Bill Brazelton, PhD
Title: Assistant Professor - Biology
A major research focus of the Brazelton lab is the study of bacteria and archaea who inhabit rock-hosted environments influenced by a process known as serpentinization. These environments host a set of extreme environmental conditions characterized by high concentrations of hydrogen gas, methane, and other simple organic compounds that are attractive food and energy sources for microbes. Serpentinization has been occurring on Earth ever since it became cool enough to have liquid water, and it is also expected to occur on other planets, such as Mars. Therefore, the lessons we learn by studying the weird archaea and bacteria associated with serpentinization are likely to help us understand the origin, distribution, and evolution of life in the solar system.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: bacteria, archaea, environmental microbiology
Email: william.brazelton@utah.edu
Mary Bronner, MD
Title: Professor - Pathology
My research involves molecular diagnostic anatomic pathology and biomarkers of cancer risk in chronic inflammatory gastrointestinal diseases, particularly idiopathic inflammatory bowel disease.
3i Bridge/Pillar: Cancer
Keywords: ulcerative colitis, Crohn’s disease, molecular diagnostics
Email: mary.bronner@aruplab.com
Jessica Brown, PhD
Title: Assistant Professor - Pathology
Our lab studies the pathogenesis of the fungus Cryptococcus neoformans and its interplay with the immune system.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: fungi, Cryptococcus, antimicrobials
Email: jessica.brown@path.utah.edu
Sarah Bush, PhD
Title: Associate Professor - Biology
My research focuses on the evolutionary consequences of interspecific interactions and the evolution of biodiversity. Specifically, I address these themes by investigating the co-evolutionary ecology of hosts and their parasites, primarily birds and ectoparasitic feather lice. My research involves experimental evolution, comparative research, and faunal surveys.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Co-evolution, Ecology, Host-parasite interactions, biodiversity, biogeography, and systematics
Email: bush@biology.utah.edu
Kristina Callis Duffin, MD
Title: Associate Professor - Dermatology
Dr. Duffin’s research interests include medical co-morbidities of psoriasis, clinical trials of psoriasis therapeutics, and psoriasis outcomes measures. She is the co-director of the Utah Psoriasis Initiative, a research project aimed at correlating the phenotypic and genotypic features of psoriasis.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: psoriasis
Email: kristina.duffin@hsc.utah.edu
Robert Campbell, PhD
Title: Research Assistant Professor - Internal Medicine (General Internal Medicine)
The primary goal of Dr. Campbell’s research is to determine how blood clots induce robust transcriptional and translational responses in immune cells, which promotes inflammation and thrombosis. During my training, I have focused on dissecting the mechanisms behind how cells alter coagulation under normal and disease situations. Recently, I have begun to examine how hemostasis and thrombosis
3i Bridge/Pillar: Cardiovascular
Keywords: thrombosis, platelets, infection, inflammation, aging
Email: rcampbell@u2m2.utah.edu
Lisa Cannon-Albright, PhD
Title: Professor - Internal Medicine (Genetic Epidemiology)
3i Bridge/Pillar: Cancer
Keywords: genealogy, UPDB, pedigree, predisposition gene
Email: lisa.albright@utah.edu
Mario Capecchi, PhD
Title: Distinguished Professor - Human Genetics
Our laboratory is working on the interactions between the CNS and the immune system both in terms of maintaining homeostasis as well as, when aberrant, leading to pathology.
3i Bridge/Pillar: Neuroscience
Keywords: microglia, gene targeting, hox genes, obsessive compulsive spectrum disorders, mouse models
Email: capecchi@genetics.utah.edu
Demián Cazalla, PhD
Title: Associate Professor - Biochemistry
Our laboratory uses biochemistry and molecular biology to dissect the molecular functions of non-coding RNAs and their role in viral infections.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: herpesvirus, miRNA, non-coding RNA, gene expression
Email: dcazalla@biochem.utah.edu
Bhagirath Chaurasia, PhD
Title: Research Assistant Professor - Nutrition and Integrative Physiology
To understand which tissues are most sensitive to ceramide accumulation. Delineating molecular mechanism via which nutrients are sensed by sphingolipids. The regulation of fat metabolism by the immune system.
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: lipotoxicity, insulin, diabetes, inflammation
Karin Chen, MD
Title: Assistant Professor - Pediatrics (Allergy/Immunology)
My bench and translational research investigations focus on the genetic and mechanistic origins of pediatric-onset primary immunodeficiency and primary immune dysregulatory diseases. The overarching goal of my research is to improve diagnosis and treatment by understanding the genetic and pathophysiologic basis of these diseases.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: primary immunodeficiency disease, NF-kappaB, NFKB2, immune dysregulation, genomics
Email: karin.chen@hsc.utah.edu
Xinjian Chen, MD, PhD
Title: Assistant Professor - Pathology
We study targeted therapy in combination with immunotherapy for cancer treatment, using graphene oxide-formulated anticancer antibodies along with tumor-targeted delivery of immune cytokines. Our goal is to convert tumor necroptosis into tumor vaccine in situ to overcome intratumor tolerogenic microenvironment. We also investigate mechanisms of cancer cell necroptosis brought about by graphene oxide-formulation anticancer antibodies.
3i Bridge/Pillar: Cancer
Keywords: anticancer antibodies, graphene oxide, necroptosis
Email: xinjian.chen@path.utah.edu
Mingnan Chen, PhD
Title: Assistant Professor - Pharmaceutics and Pharmaceutical Chemistry
We are interested in invention of immune tolerant peptide and protein materials for medicine. We also integrate principles of immunology, protein engineering, and drug targeting to develop immunotherapeutics.
3i Bridge/Pillar: Cancer
Keywords: immune tolerated materials, vaccine, cancer immunotherapy, autoimmunity, protein engineering, drug development.
Email: mingnan.chen@utah.edu
Samuel Cheshier, MD, PhD
Title: Associate Professor - Neurosurgery
My research focuses on promoting macrophages to specifically target and "eat" pediatric brain tumors. We aim to combine immune-therapies and standard of care treatments to promote macrophage phagocytosis of tumor cells.
3i Bridge/Pillar: Cancer
Keywords: macrophage, immune-therapy, CD47, medulloblastoma, pediatric, brain tumor
Email: samuel.cheshier@hsc.utah.edu
Jan Christian, PhD
Title: Professor - Neurobiology and Anatomy
The Christian lab uses targeted mutagenesis in mice together with cell biological and biochemical approaches in Xenopus embryos to study cell-cell signaling in development and disease. We identified Tril (Toll-like receptor4 interactor with leucine-rich repeats) as a gene that coordinately regulates both arms of the transforming growth factor beta (TGFß) signaling cascades, and also coordinately regulates E-cadherin based cell-cell adhesion and Wnt pathway activation. Our ongoing studies suggest that Tril activates an NF-KB independent, non-canonical Toll-like receptor signaling cascade to do so.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Tril, Tlr4, BMP, Wnt, Xenopus, mouse
Email: Jan.Christian@hsc.utah.edu
Stacey Clardy, MD, PhD
Title: Assistant Professor - Neurology
Research focuses on the epidemiology and pathophysiology of autoimmune neurologic disorders (neural autoantibody mediated) and immune-mediated neurologic disorders, including autoimmune encephalitis and paraneoplastic neurologic syndromes, stiffperson syndrome, neuromyelitis optica spectrum disorder, neurosarcoidosis and CVID-associated granulomatous Disease and associated neurologic complications of CVID.
3i Bridge/Pillar: Neuroscience
Keywords: autoimmune neurology, neuroimmunology, paraneoplastic, encephalitis, neuromyelitis optica, CVID (common variable immunodeficiency)
Email: Stacey.Clardy@hsc.utah.edu
Fredric Clayton, MD
Title: Professor - Pathology
Study of allergic disorders, particularly eosinophilic esophagitis and EGPA.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: allergy, eosinophilic esophagitis, EGPA, Churg-Strauss, IgG4
Email: fred.clayton@path.utah.edu
Donna Cross, PhD
Title: Research Associate Professor - Radiology and Imaging Sciences
The Neuroimaging and Biotechnology Lab (NiBL) uses imaging technologies to develop new diagnostics and therapeutic options for neurodegenerative diseases such as Alzheimer’s disease, as well as traumatic brain injury and spinal cord injury. Therapies to support processes such as neuroinflammation, axonal transport and cytoskeletal stabilization are a focus. Other projects include the investigation and optimization of delivery methods for cancer immunotherapies.
3i Bridge/Pillars: Neuroscience
Keywords: MRI, PET, focused ultrasound, Alzheimer’s disease, traumatic brain injury, spinal cord injury, theranostics
Email: D.Cross@utah.edu
Colin Dale, PhD
Title: Associate Professor - Biology
My research focuses on symbiotic relationships involving bacteria and animals, particularly insects. Many insects are known to harbor mutualistic bacterial symbionts that play important roles in host nutrition and defense. My research explores the nature of these symbiotic interactions using an integrative approach that employs genomic, transcriptomic, molecular genetic and molecular evolutionary analyses. We explore a range of topics including: (i) the causes and consequences of genome degeneration in bacterial symbionts, (ii) the molecular basis of interactions between insects and symbiotic bacteria, and (iii) the use of symbionts to express the foreign gene in insects of medical and agricultural importance.
3i Bridge/Pillars: Host-Microbe Interactions
Keywords: Microbiology and molecular evolution, insects and endosymbionts
Email: colin.dale@utah.edu
Darrell Davis, PhD
Title: Professor - Medicinal Chemistry
The discovery, validation, and development of small molecule inhibitors of viral translation. Specific viruses of interest include Zika, Dengue, Powassan, and HCV. We are particularly interested in how potential therapeutic molecules might affect mechanisms that differentiate viral from host translation.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: viral inhibition, translation, RNA, flavivirus, Zika, Dengue, Powassan, HCV
Email: darrell.davis@utah.edu
Denise Dearing, PhD
Title: Distinguished Professor - Biology
My research focuses on ecological factors and physiological constraints that influence foraging behavior and the evolution of diet breadth in mammalian herbivores.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: evolution, microbiome, plants, ecology
Email: dearing@bioscience.utah.edu
Michael Deininger, MD, PhD
Title: Professor - Internal Medicine (Hematology/BMT)
Our lab is interested in the biology of myeloid malignancies, such as chronic and acute myeloid leukemia. We aim to understand the mechanisms governing malignant transformation, identify vulnerabilities and exploit these weaknesses as therapeutic targets.
3i Bridge/Pillar: Cancer
Keywords: myeloid malignancies, leukemia, targeted therapy, tyrosine kinase inhibitors, cancer metabolism
Julio Delgado, MD
Title: Professor - Pathology
Translational research in the field of transplantation immunology and immunogenicity to biologicals.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: transplantation, immunology, alloreactivity, immunogenicity, biologicals
Email: julio.delgado@aruplab.com
Mark Deneau, MD
Title: Assistant Professor - Pediatrics (Pediatric Gastroenterology)
Created a consortium of 46 international centers to study a rare disease, pediatric primary sclerosing cholangitis, in a large cohort of children. Risk stratification, prognostic modeling, comparative effectiveness of available therapies, transplant outcomes and search for surrogate endpoints.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: inflammatory bowel disease, especially primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH)
Email: Mark.Deneau@hsc.utah.edu
Tony Donato, PhD
Title: Associate Professor - Internal Medicine (Geriatrics)
The primary research direction in the Translational Vascular Physiology lab is determining how arteries develop inflammation and oxidative stress with aging and increase our risk of developing vascular diseases. Another recent focus is understanding the vascular etiology of a two of rare diseases, systemic sclerosis (SSC) and cerebral cavernous malformations (CCM), and providing novel and important therapeutics to patients.
3i Bridge/Pillar: Cardiovascular
Keywords: arteries, endothelium, inflammation, oxidative stress, aging, rare diseases
Email: tony.donato@hsc.utah.edu
Richard Dorsky, PhD
Title: Professor - Neurobiology and Anatomy
The Dorsky laboratory studies the role of the Wnt signaling pathway in CNS neurogenesis. We use zebrafish as a model organism, focusing on the regulation of Wnt target genes in the CNS by Tcf transcription factors. Our current work focuses on neurogenesis in the spinal cord and the hypothalamus, addressing three important questions.
1) Which cells require Wnt/Tcf signaling?
2) What are the molecular targets of Tcf proteins?
3) How does Wnt/Tcf-dependent neurogenesis contribute to physiology and behavior?
3i Bridge/Pillar: Neuroscience
Keywords: Wnt signaling, zebrafish, developmental neurobiology, spinal cord injury, hypothalmus
Micah Drummond, PhD
Title: Associate Professor - Physical Therapy
The focus of our research is to examine the mechanisms that are associated with disuse-induced muscle atrophy and metabolic dysfunction in aging.
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: aging, muscle, inflammation, metabolism, insulin resistance, ceramide
Email: micah.drummond@hsc.utah.edu
Nels Elde, PhD
Title: Associate Professor - Human Genetics
My research program investigates host-microbe interfaces and the evolutionary impact of these interactions on genomic and cellular complexity. Protein surfaces at these interfaces often evolve in a manner resembling molecular arms races, providing a conspicuous means to investigate mechanisms underlying the process of evolution.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: virus, pathogen-driven evolution, mimicry, experimental evolution
Email: nelde@genetics.utah.edu
Elena Enioutina, MD, PhD
Title: Research Associate Professor - Pediatrics (Pediatric Clinical Pharmacology)
Dr. Enioutina has long-standing interest in the prophylaxis of infectious diseases goes back to medical school years. Immune senescence and modulation of immune responses in aged animals by cholesterol lowering drugs was the topic of her Ph.D. work. Her current research involves the understanding of the relationship between the activity of cord blood myeloid derived suppressor cells and neonatal susceptibility to infections, and discovering therapeutic options aimed to improve immune responsiveness of newborns.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: immunopharmacology, Myeloid-Derived Suppressor Cells (MDSCs), vaccination, chlamydia infections
Email: elena.enioutina@hsc.utah.edu
Kimberley Evason, MD, PhD
Title: Assistant Professor - Pathology
The overarching goal of the Evason laboratory is to investigate mechanisms involved in liver cancer (hepatocellular carcinoma, HCC) in order to develop improved therapies. Our main experimental model is the zebrafish, which represents an excellent model system for studies of human HCC, given the powerful genetics and large brood size of this vertebrate animal, as well as the histologic and genetic similarities between zebrafish and human HCC.
3i Bridge/Pillar: Cancer
Keywords: zebrafish, liver, cancer, Wnt, beta-catenin
Brian Evavold, PhD
Title: Professor - Pathology
My research centers on how antigen recognition by T cells determines cell phenotype, fate, and outcome of the adaptive immune response. Understanding the mechanisms driving T cell activation provides novel insight into the basis of autoimmune disease and effective response to infections.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords:
Email: brian.evavold@path.utah.edu
Julio Facelli, PhD
Title: Professor - Biomedical Informatics
Facelli’s research interests are centered
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: biomedical data integration, biomedical data mining, biomedical temporal reasoning, protein structure prediction
Email: julio.facelli@utah.edu
Keke Fairfax, PhD
Title: Assistant Professor - Pathology
IL-4 and immuno-modulation are hallmarks of parasitic infections, my laboratory broadly focuses on using the helminth parasite Schistosoma
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Schistosomiasis, B cells, macrophages, maternal infection, pathogenesis, helminths
Email: keke.fairfax@path.utah.edu
John Fang, MD
Title: Professor - Internal Medicine (Gastroenterology)
His clinical interests include treatment, diagnosis, and continuing care for gastrointestinal diseases and endoscopy.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Eosinophilic Esophagitis, Barrett's Esophagus, endoscopy, gastrointestinal
Email: John.Fang@hsc.utah.edu
Jim Fang, MD
Title: Professor - Internal Medicine (Cardiovascular Medicine)
My interests include the pathophysiology of heart failure with preserved ejection fraction as well as heart failure with recovered ejection fraction.
3i Bridge/Pillar: Cardiovascular
Keywords: heart failure, diastolic heart failure, myocardial recovery
Email: james.fang@hsc.utah.edu
Bingjian Feng, PhD
Title: Research Assistant Professor - Dermatology
Bing’s lab at the University of Utah conducts research on disease gene hunting, elucidation of disease mechanisms, classification of genetic variants as pathogenic or benign for clinical genetic testing, clinical biomarker identification, early diagnostic test development, and the implementation and dissemination of screening and diagnostic tools in a clinical setting. We also develop novel biostatistical and bioinformatics methods and design software tools. Currently, our research focuses on psoriasis, psoriatic arthritis, breast cancer, prostate cancer, and head and neck cancer.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: bioinformatics, genetic testing, risk prediction, diagnosis, psoriatic arthritis, biomarker
Email: bingjian.feng@hsc.utah.edu
Gabriel Fine, MD
Title: Assistant Professor - Radiology and Imaging Sciences
Our goal is to develop novel immunotherapies and optimize delivery methods for solid tumors. We are currently targeting hepatocellular carcinoma using cellular therapies such as TCR-transduced T cells. We are also investigating optimal delivery methods and in vivo imaging assessments of efficacy to ultimately improve treatment responses and diminish toxicity.
3i Bridge/Pillar: Cancer
Keywords: cancer immunotherapy, interventional oncology, interventional radiology, CAR T cells, TCR-transduced T cells, monoclonal antibodies
Email: Gabriel.Fine@hsc.utah.edu
Matt Firpo, PhD
Title: Research Associate Professor - Surgery
Firpo's cancer research interests focus on improving intervention and detection strategies for pancreatic cancer. In collaboration with multiple cancer investigators, much of Firpo's efforts involve projects designed to investigate the underlying biology of pancreas cancer. The ultimate goal of these projects is to provide supporting justification for subsequent clinical uses.
3i Bridge/Pillar: Cancer
Keywords: pancreatic cancer, therapeutics
Email: Matt.Firpo@hsc.utah.edu
Mark A. Fisher, PhD
Title: Associate Professor, Pathology
Our work covers two distinct areas of microbiology. The first is focused on the development of novel diagnostics for clinical microbiology, primarily in the areas of bacteriology and antimicrobial susceptibility testing. The second is aimed at improving our understanding of the flea-borne transmission of plague through studies in both microbial genetics and flea innate immunity.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: plague, vector, transmission, clinical microbiology, MALDI-TOF MS
Email: mark.fisher@aruplab.com
Irma Fleming, MD
Title: Assistant Professor - Surgery
Dr. Fleming participates in a multidisciplinary team approach to the care of burn patients.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: burn injury, sepsis
Email: Irma.Fleming@hsc.utah.edu
Tracy Frech, MD
Title: Associate Professor - Internal Medicine (Rhuematology)
My research focus is of the vasculopathy on systemic sclerosis (SSc). Our clinical and translational science lab studies vascular physiology in digital ulcers and gastrointestinal tract dysfunction in SSc.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: systemic sclerosis, Scleroderma, digital ulcers, gastrointestinal tract, Raynaud's phenomenon, renal crisis
Email: Tracy.Frech@hsc.utah.edu
Michael L. Free, PhD
Title: Professor - Metallurgical Engineering
Our research group focuses on improving metal extraction and purification, corrosion mitigation and recycling, and materials synthesis and evaluation for new technologies such as chemical sensors, all of which is designed to make our world better and our way of life more sustainable.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: metals, chemical processing, electrochemistry, sensors, corrosion
Email: michael.free@utah.edu
Robert Fujinami, PhD
Title: Professor - Pathology
Viral infections of the central nervous system often result in encephalitis which is a risk factor for epilepsy. My lab has developed a new “hit and run” model to study virus-induced epilepsy where a virus infection alters central nervous system connectivity, the virus is cleared by the immune response and epilepsy occurs after the virus is gone. This has opened up how we think about epilepsy.
3i Bridge/Pillar: Neuroscience
Keywords: demyelinating disease, virus-induced autoimmune disease, multiple sclerosis, viral pathogenesis, seizures, epilepsy
Email: robert.fujinami@hsc.utah.edu
Katsu Funai, PhD
Title: Assistant Professor - Physical Therapy & Athletic Training
Our laboratory is interested in the intracellular fate of lipids into membrane phospholipids and how they affect cellular energetics. We hypothesize that some of the metabolic defects induced by obesity can be explained by changes in membrane lipid composition.
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: metabolism, lipids, mitochondria, bioenergetics, obesity, exercise
Email: kfunai@health.utah.edu
Hamid Ghandehari, PhD
Title: Professor - Pharmaceutics and Pharmaceutical Chemistry
Research in our lab involves design and development of polymeric and inorganic materials for controlled drug and gene delivery. The platforms in our lab can easily be utilized for localized delivery of anti-infective agents to maximize efficacy and reduce side effects.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: drug delivery, nanotechnology
Ramkiran Gouripeddi, MBBS
Title: Research Assistant Professor - Biomedical Informatics
My research focuses on developing novel informatics methods and their application to clinical and translational research. I use advanced computational and artificial intelligence methods for domain specific biomedical problems that require integration of distributed information and omics data for big data analytics, and management of their metadata and semantics. More particularly, I am interested in discovering the interactions of the exposome and microbiome with the host's immunome in metabolic disorders.
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: clinical and translational research informatics, semantic integration of information, distributional semantics, metadata discovery, exposomics, machine learning
Email: ram.gouripeddi@utah.edu
David Grainger, PhD
Title: Distinguished Professor - Biomedical Engineering
Our work seeks to improve the performance of implants in the body using local drug release, and enhance implant-tissue interfaces by reducing inflammation and infection. We also develop 3-D in vitro cell-based models to analyze drug toxicity, and in vivo assessments of nanoparticle biodistributions.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: medical device, drug delivery, inflammatory response, infection, local therapy
Email: David.Grainger@hsc.utah.edu
John Greenlee, MD
Title: Professor - Neurology
My research is in the area of autoimmune and paraneoplastic neurological disease. Studies involve use of organotypic slice cultures and animal models to study human autoimmune neurological disease.
3i Bridge/Pillar: Neurosciences
Keywords: autoimmune neurology, paraneoplastic neurological syndromes, paraneoplastic cerebellar degeneration, organotypic brain cultures, autoantibodies, animal models
Email: john.greenlee@hsc.utah.edu
Christopher Gregg, PhD
Title: Assistant Professor - Neurobiology and Anatomy
Discovering how epigenetic mechanisms shape behavior and disease
3i Bridge/Pillar: Neuroscience
Keywords: epigenetics, genomics, brain disease, mental health, machine learning, CRISPR gene editing
Email: chris.gregg@neuro.utah.edu
David Grunwald, PhD
Title: Professor - Human Genetics
Genetics of susceptibility to osteoarthritis and the role of inflammation in osteoarthritis.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: osteoarthritis, inflammation, innate immunity, Ripk2, mouse models
Email: dgrunwal@genetics.utah.edu
Adiseshu Gundlapalli, MD, PhD
Title: Professor - Internal Medicine (Epidemiology)
As one of the few physicians in the intermountain west with training and experience in both infectious diseases and clinical immunology, his clinical interests include infectious diseases and non-AIDS immune deficiencies in adults. He provides both out-patient and in-patient consultations for primary and secondary immune deficiencies as well as community and hospital acquired infections. His other clinical interests include biodefense, emerging infections such as pandemic influenza, preparedness for public health emergencies, infection prevention/hospital epidemiology and medical informatics. He considers it a privilege to serve patients and welcomes referral requests from providers in these clinical areas.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: influenza, emerging communicable diseases, diagnostic techniques
Email: Adi.Gundlapalli@hsc.utah.edu
Steve Guthery, MD
Title: Professor - Pediatrics (Pediatric Gastroenterology)
Dr. Guthery is the Chief of the Division of Pediatric Gastroenterology, Hepatology, Nutrition. His interests include the care of infants, children and adolescents with Crohn's disease, ulcerative colitis and liver disease. His research involves understanding the genetic basis of and improving treatments for these conditions.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: inflammatory bowel disease, Crohn's, ulcerative colitis, genetics of childhood liver disease
Email: stephen.guthery@hsc.utah.edu
Hans Haecker, PhD
Title: Professor - Pathology
The major focus of our lab is on innate immunity and inflammation, with projects ranging from molecular mechanisms of signal transduction to translational aspects of drug development. We explore how innate immune cells recognize and respond to pathogens (with focus on Toll-like receptors (TLRs)), how genetic mutations in innate immunity contribute to inflammatory and auto-immune diseases (with focus on systemic lupus erythematosus and psoriasis), and how obtained information can be used to develop novel therapeutic strategies (with focus on TLR-inhibitors).
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Innate immunity, inflammation, signal transduction, Toll-like receptor, drug development, hematopoiesis
Email: hans.haecker@path.utah.edu
Scott Hale, PhD
Title: Assistant Professor - Pathology
My laboratory studies T cells and their role in the generation of immunological memory in response to infection and immunization. We are particularly interested in understanding the genetic and epigenetic programs that regulate the differentiation and maintenance of memory helper T cell subsets. We are currently investigating whether targeting epigenetic programming of helper T cell differentiation can enhance T cell help to B cells to generate improved protective antibody responses against viral pathogens.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: helper T cells, immunological memory, viral immunology, DNA methylation, epigenetics
Email: scott.hale@path.utah.edu
Ahmad Halwani, MD
Title: Assistant Professor - Internal Medicine (Hematology/BMT)
My research focuses on understanding efficacy and safety of novel therapeutics in patients with lymphoma. I also research informatics approaches to leverage electronic health record data to optimize patient care.
3i Bridge/Pillar: Cancer
Keywords: CLL, lymphoma, and health care
Email: Ahmad.Halwani@hsc.utah.edu
Ming Hammond, PhD
Title: Associate Professor - Chemistry
The Hammond lab has a dual focus on engineering nucleic acids as programmable tools for molecular imaging and gene control, and on understanding the chemistry and biology of nucleotide-based signaling molecules in bacteria and mammalian cells.
We are one of the first labs to develop fluorescent biosensors made of RNA for live cell imaging of enzyme activity. These sensors are designed by combining a riboswitch domain, which is an RNA that changes conformation upon binding a small molecule ligand, and a fluorophore-binding domain. Ligand selectivity is dictated by the riboswitch domain and can even be reprogrammed with single nucleotide changes.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: biosensors, enzymes, cell imaging, RNA, riboswitch domain
Email: ming.hammond@utah.edu
Kimberly Hanson, MD
Title: Associate Professor - Internal Medicine (Infectious Disease)
My research is focused on the development and validation of novel diagnostic tests for infectious diseases.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: diagnostics, infectious disease
Email: kim.hanson@hsc.utah.edu
Mary Elizabeth Hartnett, MD
Title: Professor - Ophthalmology & Visual Sciences
Studies mechanisms of normal and aberrant angiogenesis, particularly related to diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Eye diseases, treatments for Retinopathy of prematurity
Email: ME.Hartnett@hsc.utah.edu
Xiao He, MD, PhD
Title: Research Assistant Professor - Pathology
We are studying role of GILT (gamma-IFN-inducible lysosomal thiol reductase), an enzyme involved in Ag processing, in thymus selection and in pathogenesis of autoimmune diseases, such as type I diabetes.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: GILT, Ag processing, thymus selection, type I diabetes
Email: xiao.he@path.utah.edu
My Helms, PhD
Title: Assistant Professor - Internal Medicine (Pulmonary)
The main interests of my laboratory include investigating the role and regulation of epithelial ion channels (ENaC) in lung health and inflammatory diseases. We employ contemporary molecular, cellular, biochemical, and electrophysiological assays to address important mechanistic questions with the long-term goal of developing novel therapeutics for channelopathies and inflammatory diseases.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: epithelial sodium channel (ENaC), oxidative stress, post-translational modification, S-glutathionylation (P-SSG)
Email: my.helms@hsc.utah.edu
Adam Hersh, MD, PhD
Title: Associate Professor - Pediatrics (Infectious Disease)
Clinical epidemiology, health services research focusing on improving the quality and safety of antimicrobial prescribing.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords:
Email: Adam.Hersh@hsc.utah.edu
Aimee Hersh, MD
Title: Associate Professor - Pediatrics (Rhuematology)
My research focuses on understanding the long-term/adult outcomes of pediatric rheumatic disease, and the impact of transition from pediatric to adult care on health outcomes for young adults with chronic illness. I am also interested in the genetics of pediatric-onset rheumatic disease and its relationship to treatment response and outcomes.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Pediatric rheumatology, outcomes, systemic lupus erythematosus, transition, genetics
Email: Aimee.Hersh@hsc.utah.edu
Chris Hill, D. Phil
Title: Distinguished Professor - Biochemistry
We take structural and biochemical approaches to understanding the mechanisms of biological processes. We study multiple areas of biology, including HIV-host interactions. These include cellular pathways that are either coopted to support viral replication or function in innate immunity.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: HIV, virus-host interactions, protein structure, Cryo-EM, X-ray crystallography
Email: chris@biochem.utah.edu
Harry Hill, MD
Title: Professor - Pathology
Dr. Hill’s research is investigating the role of cytokines, the hormones of the immune system in inflammation and disease including coronary artery disease, autoimmune disorders such as rheumatoid arthritis and multiple sclerosis, and is investigating, along with his colleagues, the molecular causes of primary immune deficiencies including Job Syndrome of Hyper IgE and Recurrent Infections, Chronic Granulomatous Disease and, more recently Common Variable Immune Deficiency using next generation sequencing as well as other molecular techniques.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: primary immune deficiency, neutrophils, antibodies, inflammation, cytokines
Email: harry.hill@path.utah.edu
Robert Hitchcock, PhD
Title: Associate Professor - Bioengineering
Our laboratory research efforts are motivated by the need for new medical device technologies and designs. We work in the fields of imaging and biosensors. Our projects almost always come from an unmet clinical need and are managed using a “design control” perspective. We work closely with clinicians and other researchers to bring a diverse set of technical and thinking skills to our projects. The lab has been involved with launching several new medical products through startup companies and we know what it takes to move technology from the lab to the clinic.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: medical device, imaging, biosensors
Email: r.hitchcock@utah.edu
Julie Hollien, PhD
Title: Associate Professor - Biology
Our overall goal is to understand the mechanisms controlling mRNA turnover and the relationships between mRNA stability, localization, and cellular stress pathways. We are currently focused on how cells employ mRNA decay in regulating endoplasmic reticulum (ER) function.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: endoplasmic reticulum, stress responses, mRNA
Email: hollien@biology.utah.edu
Sheri Holmen, PhD
Title: Professor - Surgery
Dr. Holmen’s Lab aims to define critical targets in cancer cells that can become the focus for therapeutic intervention. Current efforts utilize a genetic approach to address this question in tumors that are generally refractory to conventional therapies, including metastatic melanoma and glioblastoma. Identified targets are being further validated using pharmacological inhibitors of clinical importance such that laboratory findings can be quickly translated to the clinic.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: glioma, melanoma, mouse models of cancer, virology, oncogenes, genes, tumor suppressor
Email: Sheri.Holmen@hci.utah.edu
Janet Iwasa, PhD
Title: Assistant Professor - Biochemistry
My group creates information-rich and visually compelling animations that capture current hypotheses on diverse molecular and cellular processes. These visualizations have broad applications in scientific research, communication, education and outreach. We are also interested in creating new tools and workflows that will enable researchers to more readily create dynamic visualizations of the processes they study.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: visualization, animation, outreach
Email: jiwasa@biochem.utah.edu
Karen James, MD
Title: Assistant Professor - Pediatrics (Pediatric Rhuematology)
Dr. James’ clinical interests include vasculitis, systemic lupus erythematosus, dermatomyositis, autoinflammatory diseases and juvenile idiopathic arthritis. She also evaluates patients with musculoskeletal and joint pain. Her research focuses on diagnosis, treatment and outcomes of children diagnosed with vasculitis.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: vasculitis, systemic lupus erythematosus, dermatomyositis, autoinflammatory diseases
Email: Karen.E.James@hsc.utah.edu
Peter Jensen, MD
Title: Professor - Pathology
We study the mechanisms that underlie antigen processing and presentation for T cell recognition, and the role of classical and non-classical MHC molecules in the innate and adaptive immune systems. Our work has relevance to type 1 diabetes, other autoimmune diseases, and cancer immunology.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: MHC, HLA, Antigen processing, T cells, diabetes
Email: peter.jensen@path.utah.edu
Mick Jurynec, PhD
Title: Research Assistant Professor - Orthopaedics
My group works to discover and understand the functions of genes underlying the onset and progression of osteoarthritis. We use a combination of approaches including human genetics, bioinformatics, and model organisms (zebrafish and mouse) to elucidate the molecular and biological mechanisms that lead to changes in the synovial joint and contribute to the osteoarthritis phenotype.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: osteoarthritis, arthritis, human genetics, inflammation, mouse models, zebrafish
Email: mjurynec@genetics.utah.edu
Richard Kanner, MD
Title: Professor - Internal Medicine (Pulmonary)
COPD, Health Effects of Air Pollution
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: COPD, PM2.5
Email: richard.kanner@hsc.utah.edu
Talia Karasov, PhD
Title: Biology
Our research focuses on the genetics of interactions between plants and their microbes. Using a combination of molecular and computational methods, we study the mechanisms by which microbes become pathogenic on plants and how microbial pathogens evolve to colonise host species with distinct immune systems
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: genomics, evolution, plant-microbe interactions, microbiome, immunity
Email: tkarasov@tuebingen.mpg.de
Michael Kay, MD, PhD
Title: Professor - Biochemistry
Our protein design and peptide chemistry lab develops mirror-image D-peptide inhibitors against a broad range of targets. We are particularly focused on inhibiting viral entry (in HIV and Ebola) and bacterial toxins (e.g., Shiga).
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: phage display, protein design, D-peptides, HIV, drug discovery, Shiga toxins
Email: kay@biochem.utah.edu
Aaron Kobernick, MD
Title: Assistant Professor - Dermatology
With collaborators from Colorado Children's, The University of Arizona, and National Jewish Health, we seek to define and explore the problem of childhood asthma on the Navajo Nation. Through funding from the NIH, we are currently engaged with the Navajo community, schools and clinics to improve care for asthmatic children - and then study the effectiveness of our intervention.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: allergy, asthma, food allergy, oral immunotherapy, Navajo
Email: Aaron.Kobernick@hsc.utah.edu
John Kriesel, MD
Title: Research Associate Professor - Internal Medicine (Infectious Disease)
Dr. Kriesel's primary interests here are in translational and clinical research. He discovered a major genetic contributor to human cold sores. His research projects involve strategies for the treatment of herpes simplex virus infections, and microbiologic triggers of autoimmune diseases, including multiple sclerosis and sarcoidosis.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: next-generation sequencing, RNA-seq, Multiple Sclerosis, Sarcoidosis
Email: john.kriesel@hsc.utah.edu
Tracey Lamb, PhD
Title: Associate Professor - Pathology
We are particularly interested in factors affecting the generation of a robust immune response to kill and remove the infection. We also work on determining the molecular mechanisms mediating vascular activation during malaria.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: malaria, Plasmodium, blood
Email: tracey.lamb@path.utah.edu
Eszter Lazar-Molnar, Ph.D.
Title: Assistant Professor - Pathology
Translational research for diagnostic test development and optimization in the area of transplantation immunology, immunodeficiency, and immunogenicity to biologicals.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: HLA, transplantation, transplant monitoring, T cell proliferation, T cell costimulation, immunogenicity, biologicals, immunotherapy
Molly Leecaster, PhD
Title: Research Associate Professor - Internal Medicine (Epidemiology)
My research focuses on understanding the associations between behavior and infectious disease dynamics. We use wireless sensor networks and electronic health records to collect data on person-to-person and person-to-environment contacts that have the potential to mediate transmission. We use dynamic models and simulations to estimate transmission parameters and test potential interventions to control spread of infection. My statistical interests include spatial models, sample design, and epidemiology.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: social and dynamic network analysis, healthcare-associated infection, biostatistics
Email: Molly.Leecaster@utah.edu
Ellen Leffler, PhD
Title: Visiting Assistant Professor - Human Genetics
Our research focuses on evolutionary adaptation to infectious disease, especially malaria, in humans and other primates. We use bioinformatic and population genomic approaches to study the origin, evolution, and consequences of genetic variation that influences infectious disease susceptibility.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: malaria, evolution, genomics, primates
Email: leffler@genetics.utah.edu
Lisa Lesniewski, PhD
Title: Associate Professor - Internal Medicine (Geriatrics)
My laboratory explores mechanisms underlying age- and obesity-associated vascular and metabolic dysfunction and disease. Using genetic, pharmacologic and surgical approaches, we explore the role of mi-92a and ARF6 in vascular and metabolic dysfunction as well as atherosclerotic disease progression across the lifespan.
3i Bridge/Pillar: Cardiovascular
Keywords: aging, obesity, atherosclerosis, insulin sensitivity, glucose tolerance, endothelium
Email: Lisa.Lesniewski@utah.edu
Daniel Leung, MD
Title: Assistant Professor - Internal Medicine (Infectious Disease)
We study clinical, epidemiological, and immunological responses to intestinal infections, focusing on cholera and other pathogens of importance in resource-limited settings. We have a secondary focus on mucosal-associated invariant T (MAIT) cell biology.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Cholera, diarrhea, MAIT cells
Email: Daniel.Leung@utah.edu
Giavonni Lewis, MD
Title: Associate Professor - Surgery
Dr. Lewis has a particular focus on the care of thermal and soft tissue injuries. She participates in a multidisciplinary team approach to the care of our burn patients.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: burn injury, sepsis
Email: giavonni.lewis@hsc.utah.edu
Theodore Liou, MD
Title: Professor - Internal Medicine (Pulmonary)
We study survival and its clinical predictors in patients with cystic fibrosis (CF). We have multiple projects to study the roles of inflammation and microbial interactions in the airway. Our research has led to a search for novel antimicrobial agents from bacterial members of airway ecology. Because of our involvement in clinical care of patients with CF, we participate in many clinical trials involving novel agents for the treatment of CF transmembrane mutation defects, CF-associated inflammation and management of malnutrition associated with CF.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: cystic fibrosis, inflammation, antimicrobials
Email: ted.liou@utah.edu
Catherine Loc Carillo, PhD
Title: Research Assistant Professor - Internal Medicine (Epidemiology)
Our research is focused in developing translational studies to prevention and treatment polymicrobial infections using experimentally infected animal models. My goal is to conduct well-controlled, impartial research to investigate the possibilities of applying bacteriophages (phages) as biocontrol agents to clinically problematic infections, with particular emphasis on antibiotics resistant bacteria.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: antimicrobial resistance, bacteriophages, polymicrobial infections
Email: C.Loc.Carrillo@hsc.utah.edu
Ryan Looper, PhD
Title: Professor - Chemistry
Our lab uses chemical synthesis to probe the underlying mechanism of action of natural products. Through these efforts we develop leads for the treatment of various human diseases. A particular focus is the development of new antibiotic agents with novel mechanisms of action targeting multi-drug resistant Gram-(+) and Gram-(-) pathogens.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: antibiotics, translation, ribosome, natural products, medicinal chemistry
Email: r.looper@utah.edu
Scott McNally, MD, PhD
Title: Assistant Professor - Radiology and Imaging Sciences
Our group’s scientific mission is to optimally detect vascular disease using advanced imaging techniques, with the overall aim to improve diagnosis and treatment of cerebrovascular disease.
3i Bridge/Pillar: Cardiovascular
Keywords: magnetic resonance imaging, stroke, blood vessels, atherosclerosis, inflammation, oxidative stress
Email: Scott.Mcnally@hsc.utah.edu
Elizabeth Middleton, MD
Title: Instructor - Internal Medicine (Pulmonary)
I work within the Weyrich, Zimmerman, Rondina lab. We are primarily a platelet and megakaryocyte lab with a focus on transcriptional and translational control. My work focuses on alterations in RNA and protein expression in both human and mouse models of sepsis and other inflammatory conditions.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: platelet, megakaryocyte, sepsis, CLP, translation, transcription
Patrice Mimche, PhD
Title: Research Assistant Professor - Pathology
The focus of the Mimche lab is to determine the molecular basis of fibrosis, a tissue remodeling process that leads to scarring and organ failure. We are currently investigating the role of EphB/Ephrin-B signaling axis during organs fibrosis with a focus on Scleroderma and liver fibrogenesis. The long term goal is to utilize our findings to develop novel biomarkers and therapeutic agents for the management of fibrosis-related diseases.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: fibrosis, inflammation, angiogenesis, Eph/Ephrin, immunity, vascular damage
Email: patrice.mimche@path.utah.edu
Satoshi Minoshima, MD, PhD
Title: Professor - Radiology and Imaging Sciences
In vivo animal and human imaging of immune cells and inflammation.
3i Bridge/Pillar: Neuroscience
Keywords: imaging, PET, MRI, immune cells, inflammation
Email: sminoshima@hsc.utah.edu
Kathryn Morton, MD
Title: Professor - Radiology and Imaging Sciences
Causes and consequences of sepsis-induced neuroinflammation.
3i Bridge/Pillar: Neuroscience
Keywords: positron emission tomography, sepsis, neuroinflammation, amyloid beta
Email: Kathryn.Morton@hsc.utah.edu
Hong-Hua Mu, MD, PhD
Title: Research Associate Professor - Internal Medicine (Rhuematology)
My research has been to study how microbial agents (i.e., bacteria and mycoplasmas, and bacteria toxins)) can cause inflammatory/autoimmune diseases. We focus on the interplay of innate and adaptive immune system, role of T cell activation and differentiation in mouse models of inflammatory/autoimmune arthritis, sepsis and autoimmune colitis. Over the past two decades, we have been particularly studying how immune molecules including TLRs, MHC, co-stimulatory molecules, cytokines and chemokines are regulated by an unique mycoplasma superantigen MAM, and several other bioactive mycoplasma membrane lipoproteins which we have identified and isolated, and these microbial agents are shown to be disease pathogenic in our mouse models.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: autoimmunity, infection, cytokines, autoimmune arthritis, sepsis, and IBD
Email: Hong-hua.Mu@hsc.utah.edu
Matt Mulvey, PhD
Title: Professor - Pathology
The Mulvey lab is working to delineate both bacterial and host factors that control the ability of pathogens to colonize and persist within diverse host environments, with a major goal being the development of improved anti-bacterial therapeutics. This research utilizes genetics, microscopy, biochemistry, global gene expression analysis, and molecular biology techniques coupled with cell culture, mouse, and zebrafish infection model systems
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: bacterial pathogenesis, sepsis, urinary tract infections, gut colonization, virulence regulation, antibiotics
Email: mulvey@path.utah.edu
Charles Murtaugh, PhD
Title: Associate Professor - Human Genetics
Research in my lab focuses on development and disease of the mammalian pancreas, using mouse models as well as human cell lines and tissues. Of particular interest is the relationship between differentiation, inflammation and tumor susceptibility.
3i Bridge/Pillar: Cancer
Keywords: pancreas, pancreatitis, cancer
Email: murtaugh@genetics.utah.edu
Deborah Neklason, PhD
Title: Research Associate Professor - Epidemiology
Lynch syndrome is an inherited predisposition to colon, endometrial and other cancers due go inherited mutations in mismatch repair genes (MLH1, MSH2, MSH6, PMS2).
3i Bridge/Pillar: Cancer
Keywords: Lynch syndrome; cancer; inflammation; t-cell mediated immunity
Email: deb.neklason@hci.utah.edu
Richard Nelson, PhD
Title: Research Associate Professor - Internal Medicine (Epidemiology)
My research focuses on identifying the optimal use of scarce healthcare resources. In the realm of infectious diseases, I use the tools of health economics to inform decision making related to antibiotic prescribing and strategies to prevent transmission of multidrug-resistant organismss in the hospital.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: healthcare-associated infections, multidrug-resistant organisms, health economics, cost-effectiveness analysis
Email: Richard.Nelson@utah.edu
Ryan O'Connell, PhD
Title: Professor - Pathology
The O’Connell lab is focused on the study of noncoding RNAs, including microRNAs, that regulate immune cell development and functions in health and during diseases that include neuroinflammation, cancer, and metabolic disorders. We are also engaging in the study of intercellular communication by extracellular vesicles that transfer small RNAs and other molecules between immune cells as a novel mechanism of regulating inflammatory responses.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Noncoding RNAs, microRNAs, inflammation, T cells, dendritic cells, macrophages, metabolism, extracellular vesicles, cancer
Email: ryan.oconnell@path.utah.edu
Trudy Oliver, PhD
Title: Associate Professor - Oncological Sciences
The Oliver Lab develops mouse models of all subtypes of lung cancer including adenocarcinoma, squamous and small cell lung cancer. Our primary interests include investigating the role of the tumor immune microenvironment in lung cancer, particularly the function of neutrophils. We have identified a role for cell fate specifiers SOX2 and NKX2-1 in regulating distinct immune microenvironments in subtypes of non-small lung cancer. In addition, we have shown that small cell lung cancer is composed of distinct molecular and therapeutically-relevant subtypes, which is driven by MYC status. Our expertise includes preclinical drug testing in mice, small animal imaging, and tumor biology.
3i Bridge/Pillar: Cancer
Keywords: tumor immunity, lung cancer, mouse models, neutrophils, MYC, SOX2, single cell sequencing, gd T cells
Email: Trudy.Oliver@hci.utah.edu
Suzanne Ostrand-Rosenberg, PhD
Title: Professor - Pathology
We study the role of tumor-induced immune suppression in inhibiting antitumor immunity. Our studies have focused on two important immune suppression mechanisms that are globally present in cancer patients: myeloid-derived suppressor cells (MDSC) and the programmed death 1 T cell pathway (PD-1/PD-L1). Our studies are aimed at understanding the mechanisms responsible for the immune suppression and the development of therapeutic strategies for neutralizing the suppression.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: antitumor immunity, cancer vaccines, tumor-induced immune suppression
Email: srosenbe@umbc.edu
Shawn Owen, PhD
Title: Assistant Professor - Pharmaceutics and Pharmaceutical Chemistry
My lab utilizes protein engineering and bioconjugation techniques in developing therapeutic and diagnostic platforms to enable precision medicine. Our current research focus is on 1) controlling the systemic and cellular pharmacokinetics (PK) of antibody-based therapeutics by creating self-amplifying antibody-drug conjugates, 2) evaluating the pharmaceutic stability of antibody-based therapeutics, and 3) engineering binary/ternary complementation-based diagnostic systems that utilize luminescent reporters for detection of important biomarkers.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: antibodies, antibody-drug conjugates, therapeutics, diagnostics
Email: shawn.owen@hsc.utah.edu
Robert Paine, MD
Title: Professor - Internal Medicine (Pulmonary)
My laboratory investigates the role of alveolar epithelial cells in pulmonary innate immunity, with a particular interest in the consequences of local environmental factors (oxidative stress, hypoxia or particulate pollution) on epithelial cell expression of key molecules promoting lung defense. We participate in human studies as part of large NIH-sponsored networks investigating acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). I also direct the University of Utah Program for Air Quality, Health and Society.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: innate immunity; GM-CSF; alveolar macrophage; pneumonia; air pollution
Email: Robert.Paine@hsc.utah.edu
Alex Pastuszak, MD, PhD
Title: Assistant Professor - Surgery
My research focuses on men’s health, with my lab emphasizing genetic factors and pathways that predispose to superficial fibrosing disorders including Peyronie’s, Dupuytren’s and Ledderhose diseases. We identify and characterize genes and pathways that can lead to these conditions using forward genetic screening in affected patients, as well as in vitro assays and animal models. We examine the impact of candidate genes on inflammatory and fibrotic signaling pathways, and how these genes contribute to the molecular and cellular pathogenesis of superficial fibrosing disorders. Our work thus far has demonstrated a link between superficial fibrosing disorders and other genetically influenced conditions, and is currently examining the role of non-canonical pathways in the pathogenesis of Peyronie’s disease. The long term goal of our work is to more thoroughly understand the genetic and molecular determinants of superficial fibrosing disorders, towards the goal of facilitating diagnosis, risk stratification, and ultimately treatment of these conditions.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Peyronie’s disease, fibrosis, inflammation, fibroblast, Dupuytren’s disease, TGF-beta
Email: Alexander.Pastuszak@utah.edu
Andrew Pavia, MD
Title: Professor - Pediatrics (Pediatric Infectious Diseases)
Our group is interested in the epidemiology of diarrheal disease and predictive models, the epidemiology and diagnosis of respiratory infections, and the use of metagenomic sequencing as a diagnostic tool. We also have interest in understanding and improving the use of antibiotics.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Influenza, diarrheal disease, epidemiology, diagnostics, antivirals
Email: Andy.Pavia@hsc.utah.edu
Kathryn Peterson, MD
Title: Associate Professor - Internal Medicine (Gastroenterology)
Dr. Peterson specializes in diagnosing and treating diseases of the digestive system including Eosinophilic Esophagitis, Barrett’s Esophagus, and inflammatory bowel disease.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Eosinophilic Esophagitis, Barrett's Esophagus, inflammatory bowel disease
Vicente Planelles, PhD
Title: Professor - Pathology
The research in my lab seeks to understand various aspects of the pathogenesis by human immunodeficiency viruses. Specifically, we study (1) how HIV-1 establishes and maintains latency; how HIV-1 and related viruses evade immune responses via expression of the so called “viral accessory proteins”; and how HIV-1 modulates the host cell cycle.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: V, lentiviruses, latency, accessory genes, SIV, interferon, SAMHD1, vpr, vpx, vpu
Wayne Potts, PhD
Title: Professor - Biology
The lab has two different major projects: 1) We use experimental evolution of viruses to evaluate the role of host and pathogen genetic diversity on virulence evolution. 2) We use seminatural populations of mice to investigate the health consequences of any treatment, which to date have included a) resistance to infectious disease mediated by social status, b) dietary sugars, c) inbreeding, d) hox gene mutations, and e) pharmaceuticals; in every case our approach has proven more sensitive and powerful than conventional approaches.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: immunogenetics, host-parasite coevolution, histocompatibility genes, virulence evolution, experimental evolution, virology
Email: wp2@utah.edu
Stefan Pulst, MD
Title: Professor - Neurology
We are investigating the mechanisms of adult-onset neurodegeneration. Our studies usually begin with genetic analysis of human pedigrees followed by modeling the disease process in cultured cells or by introducing mutations into model systems. Our focus has been on the spinocerebellar ataxias (SCA2, SCA10, SCA13) and inherited forms of Parkinson disease, groups of diseases that lead to cell-type specific neurodegeneration.
3i Bridge/Pillar: Neuroscience
Keywords: neurodegeneration, human pedigrees, spinocerebellar ataxias
Email: stefan.pulst@hsc.utah.edu
Aaron Puri, PhD
Title: Assistant Professor - Chemistry
We are interested in how bacteria use small molecules to interact with each other and their environment. These molecules, known as natural products or secondary/specialized metabolites, form the basis of many compounds essential to medicine and agriculture. We use underexplored bacterial communities as new sources of natural products, and to provide biological context in order to activate the production and determine the biological function of these compounds.
Core research topics:
Bacterial interactions mediated by natural products (chemical ecology)
Isolation, structural elucidation, and biosynthesis of novel natural products
Bacterial genetics and regulation of biosynthetic gene clusters
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: bacterial pathogens, small molecules, natural products
Email: a.puri@utah.edu
Chris Reilly, PhD
Title: Professor - Pharmcology and Toxicology
Mechanisms of inhaled particulate material toxicity. TRP ion channels in pulmonary toxicology, airway diseases, inflammation and pain. Discovery of TRP channel ligands.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: environmental toxicology, TRP channels, pulmonary diseases, asthma, pain, Cytochrome P450, drug metabolism and pharmacokinetics, and mass spectrometry
Email: Chris.Reilly@pharm.utah.edu
Jacob Robson, MD
Title: Assistant Professor - Pediatrics (Pediatric Gastroenterology)
I am interested in the changing epidemiology of pediatric eosinophilic esophagitis. I am also focused on better tracking and treating
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: eosinophilic esophagitis, pediatric gastroenterology, epidemiology, esophageal fibrosis
Email: Jacob.Robson@hsc.utah.edu
John Rose, MD
Title: Professor - Neurology
Dr. Rose and his colleagues investigate diverse aspects of multiple sclerosis (MS), including the immunopathology of MS and related models, the development of new treatments for MS, early disease detection with advanced magnetic resonance imaging, and the detection of susceptibility genes for MS.
3i Bridge/Pillar: Neuroscience
Keywords: multiple sclerosis, neurology, MRI
Email: rose@neuro.med.utah.edu
June Round, PhD
Title: Associate Professor - Pathology
We work on understanding how commensal bacteria shape host immune system development and responses.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: microbiome, mucosal immunology, IBD
Email: june.round@path.utah.edu
Minna Roh-Johnson, PhD
Title: Assistant Professor - Biochemistry
Cancer cells hijack mechanisms of normal development. In a complex milieu of an animal, in which there are many different signals from many different cells, how does a cell parse through this information to know when and where to migrate? Our long term research goal is to identify these signals, how they are communicated, and how they are interpreted into a downstream response to regulate cell motility during development and cancer. We use a combination of animal models (zebrafish and mouse) and cell culture based models, taking advantage of the strengths of each system to answer outstanding questions in cancer cell biology.
3i Bridge/Pillar: Cancer
Keywords: tumor microenvironment, cell migration, cell-cell communication, macrophages, zebrafish, mouse
Email: roh-johnson@biochem.utah.edu
Matt Rondina, MD
Title: Associate Professor - Internal Medicine (General Internal Medicine)
Our research program focuses on platelet and megakaryocyte gene expression and function during thrombo-inflammatory syndromes. To answer clinically-relevant questions, we utilize primary human cells and samples from patients as well as relevant experimental model systems. Current projects in the lab span from studies in patients with infectious diseases (e.g. sepsis, dengue, influenza) to aging and cardiometabolic disorders.
3i Bridge/Pillar: Cardiovascular
Keywords: platelets, sepsis, thrombosis, megakaryocyte, and gene expression
Email: matthew.rondina@hsc.utah.edu
Michael Rubin, MD
Title: Professor - Internal medicine (Epidemiology)
I am primarily interested in health services research and implementation science encompassing the domains of medical informatics, clinical decision support, and computer simulation modeling, particularly as these relate to topics in infectious diseases and infection prevention. Relevant recent and ongoing projects include longitudinal epidemiologic analyses of multidrug-resistant organism infection rates, hospital-based interventions to reduce device-associated infections and antimicrobial prescribing, and the development of state-of-the-art computer simulation models to test novel healthcare-associated infection intervention strategies and to analyze their clinical and economic impacts.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: biomedical informatics, computer simulation, infectious diseases, infection prevention, healthcare-associated infections, antimicrobial stewardship
Email: michael.rubin@hsc.utah.edu
Jared Rutter, PhD
Title: Professor - Biochemistry
The Rutter lab is trying to understand the reciprocal relationship between metabolism and cell behavior and fate decisions.
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: metabolism, mitochondria, signaling
Email: rutter@biochem.utah.edu
Saveez Saffarian, PhD
Title: Associate Professor - Physics and Astronomy
We are an experimental Virology and Biophysics lab. Our lab has identified a relationship between HIV budding and protease activation and we are focused on the molecular mechanisms which ensure the release of fully infectious HIV virions. Our lab has also identified a mechanism for redistribution of Vesicular Stomatitis Virus polymerases along with its genome template. VSV is a prototype negative single-stranded RNA virus and shares many of its genetic mechanisms with more potent human pathogens including Ebola and Measles. While our lab is not directly focused on developing antivirals, we hope that our efforts will shed light on underlying mechanisms used by lentiviruses and negative-strand RNA viruses.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: viruses, imaging, HIV, microscopy
Email: saffarian@physics.utah.edu
Robert Schlaberg, MD
Title: Assistant Professor - Pathology
My research is focused on developing unbiased pathogen detection approaches using shotgun metagenomics. We apply shotgun metagenomics for comprehensive pathogen detection, evaluating host-pathogen and pathogen-microbiota interactions, and developing host gene expression-based diagnostic strategies.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: metagenomics, syndromic testing, host response, respiratory infections
Matthew Samore, MD
Title: Professor - Internal Medicine (Epidemiology)
My research advances the understanding of how antibiotic use has spread resistant pathogens; uncovers mechanisms of disease spread by healthcare-associated pathogens such as Clostridium
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: multidrug-resistant organisms, healthcare-associated infection, electronic health record, health information technology, prescribing practices, patient outcomes
Email: Matthew.Samore@hsc.utah.edu
Prashant Sarswat, PhD
Title: Research Associate Professor - Metallurgical Engineering
Prashant K
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: biosensors and devices, diabetes, electrochemistry, quantum dots, spectroscopy
Email: saraswatp@gmail.com
Eric Schmidt, PhD
Title: Professor - Medicinal Chemistry
We are experts in the chemistry of metabolism, including identifying known and previously unknown compounds from microbes and host animals. Our research includes the chemistry of secondary metabolites, NMR and mass spectrometry, metagenome sequencing and analysis, and biosynthesis (synthetic biology of natural products).
3i Bridge/Pillars: Host-Microbe Interactions
Keywords: natural products, antimicrobials, spectrmetry
Email: ews1@utah.edu
Mary Beth Scholand, MD
Title: Associate Professor - Internal Medicine (Pulmonary)
My research and clinical interest is Interstitial Lung Disease. This interest encompasses Idiopathic Pulmonary Fibrosis, Autoimmune Lung Diseases, and Sarcoidosis. I am the Director of the Interstitial Lung Disease Clinic. I run clinical trials focused on a cure for Idiopathic Pulmonary Fibrosis. In addition, my research focuses on phenotypic factors and genetic factors associated with Chronic Obstructive Pulmonary Diseases and Interstitial Lung Diseases.
3i Bridge/Pillars: Immune Deficiency/Dysregulation
Keywords: idiopathic pulmonary fibrosis, autoimmune lung diseases, sarcoidosis
Email: scholand@genetics.utah.edu
Craig Selzman, MD
Title: Professor - Surgery
The Selzman lab is focused on the transcriptional control, and in particular, the inflammatory response to myocardial injury and repair. In addition, we are exploring various forms of regenerative therapies for the damaged heart.
3i Bridge/Pillar: Cardiovascular
Keywords: heart failure, myocardial recovery, inflammation, regeneration, ischemia-reperfusion, NF- ΚB
Email: Craig.Selzman@hsc.utah.edu
Michael Shapiro, PhD
Title: Professor - Biology
Evolutionary genetics and developmental biology of natural and domesticated populations of vertebrates. We study how variation at the genomic level translates to developmental and phenotypic diversity in morphology and behavior.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: evolution, genetics, genomics, development, pigeon
Email: shapiro@biology.utah.edu
Jason Shepherd, PhD
Title: Associate Professor - Neurobiology and Anatomy
The goal of our research is to understand information storage, from the molecular level through in vivo neuronal networks and how these processes go awry in neurological disorders. My lab utilizes coordinated biochemical, cell biological, electrophysiological and imaging studies both in vitro and in vivo. We recently discovered a novel mechanism of neuronal communication that resembles the life-cycle of retroviruses.
3i Bridge/Pillar: Neuroscience
Keywords: neurodegenerative diseases, neurodevelopmental disorders, synaptic transmission. synaptic membranes, synaptic plasticity, learning and memory, receptor trafficking, Immediate-Early Proteins, endocytosis, Autism Spectrum Disorders, Angelman Syndrome, Fragile X Syndrome, Rett Syndrome, Alzheimer's Disease
Paul Sigala, PhD
Title: Assistant Professor - Biochemistry
We use diverse biochemical and cellular tools to understand the metabolic adaptations that enable Plasmodium malaria parasites to survive and proliferate within human red blood cells. Our goals are to broaden fundamental knowledge of fascinating and divergent parasite biology and to identify new therapeutic opportunities to target this dangerous pathogen.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: malaria, metabolism, organelle biology, heme, parasites
Email: p.sigala@biochem.utah.edu
Bob Silver, MD
Title: Professor - Obstetrics/Gynecology
My research focuses on stillbirth, placental abnormalities and autoimmune disease in pregnancy with a focus on inflammation.
3i Bridges/Pillar: Immune Deficiency/Dysregulation
Keywords: pregnancy, placenta, stillbirth, autoimmune
Email: bob.silver@hsc.utah.edu
David Stillman, PhD
Title: Professor - Pathology
The central theme of our research is the regulation of gene expression, with the goal of understanding transcriptional regulation in eukaryotes at the molecular level.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: gene regulation, yeast, transcription
Email: david.stillman@path.utah.edu
Adam Spivak, MD
Title: Assistant Professor - Internal Medicine (Infectious Disease)
My research focuses on HIV latency and persistence despite antiretroviral therapy. I am working to develop strategies to eradicate this viral reservoir. I am also working on novel clinical strategies to prevent the spread of HIV infection in our community.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: HIV, HIV latency, HIV persistence, pre-exposure prophylaxis
Email: adam.spivak@hsc.utah.edu
Zac Stephens, PhD
Title: Research Assistant Professor - Pathology
My research seeks to understand the ecological and immunological mechanisms involved in the assembly and maintenance of host-associated microbial communities. I am also interested in improvements to high-throughput sequencing and analysis techniques employed to increase our understanding of the many unknown microbial functions.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: microbiome, mucosal immunology, microbial ecology, host-microbe, metagenomics
Email: zac.stephens@path.utah.edu
Vanessa Stevens, PhD
Title: Research Assistant Professor - Internal Medicine (Epidemiology)
My work focuses on the prevention and treatment of antimicrobial-resistant infections in the healthcare environment and promoting
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Clostridioides (Clostridium)
Email: vanessa.stevens@hsc.utah.edu
Scott Summers, PhD
Title: Professor - Nutrition and Integrative Physiology
Ceramides are products of fat and protein metabolism that accumulate in individuals prone to metabolic disorders. Once ceramide levels rise above a critical threshold, tissues become unresponsive to insulin, the hormone that facilitates nutrient storage. The Summers Laboratory found that implementing pharmacological or genetic engineering strategies to block ceramide accumulation in rodents improves insulin sensitivity and prevents the onset of diabetes and fatty liver disease. Building upon these discoveries, they now seek to understand the regulatory mechanisms governing ceramide synthesis or action and to identify new therapeutic strategies for reducing ceramides to treat these pathologies.
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: lipotoxicity, diabetes, insulin resistance,
Wes Sundquist, PhD
Title: Distinguished Professor - Biochemistry
We study the cellular, molecular and structural biology of retroviruses, particularly HIV, and the roles of the ESCRT pathway in cell division and the abscission checkpoint. Major projects in our lab include studies of: 1) HIV budding, 2) designed nanoparticles, 3) ESCRT pathway functions in cell division and the abscission checkpoint, and 4) HIV capsid structure, function and restriction, particularly by the TRIM5α innate immune system.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: HIV, innate immunity, ESCRT, TRIM5alpha, nanoparticles, protein design
Email: wes@biochem.utah.edu
Sankar Swaminathan, MD
Title: Professor - Internal Medicine (Infectious Disease)
We work on gene regulation by oncogenic herpesviruses EBV and KSHV. We study how the viruses control cellular transcription and post-transcriptional processing. We also study host factors that operate epigenetically or through the innate immune response to restrict viral replication.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Epstein Barr Virus, KSHV, oncogenesis, innate immune response, epigenetic, post-transcriptional gene regulation
Kathy Sward, PhD
Title: Associate Professor - Nursing
My research focuses on biomedical informatics methods within clinical and translational research. Recent projects included a decision support protocol for pediatric ICU (PICU) ventilator management for patients with acute lung injury, and a simple PICU sepsis risk algorithm. Current work is developing an infrastructure to support integration of person-generated health data from mobile apps and sensors into research on conditions that are influenced by environmental and lifestyle factors, such as pediatric asthma. We are also exploring wearable sensors to detect stress levels in cancer caregivers.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: biomedical informatics, sensors, environment, cancer, asthma, ARDS/ALI
Email: kathy.sward@nurs.utah.edu
Dean Tantin, PhD
Title: Associate Professor - Pathology
Our lab studies the function of mammalian transcription factors and cofactors, how they control lymphocyte function and immune responses, and how they control normal and malignant stem cell/progenitor states. Our lab has major interests in the transcriptional control of immune memory and autoimmunity.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: gene regulation; immune memory, autoimmunity
Email: dean.tantin@path.utah.edu
Robert Taylor, MD, PhD
Title: Professor - Obstetrics/Gynecology
My lab studies the molecular actions of estrogen and progesterone, endometrial differentiation and immune cell recruitment, particularly as they relate to the clinical syndrome, endometriosis.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: sex steroid receptors, IL-1β signaling, neuroangiogenesis
Email: rob.taylor@hsc.utah.edu
Anne Tebo, PhD
Title: Associate Professor - Obstetrics/Gynecology
Tebo’s research is centered on the diagnosis and management of autoimmune diseases. Her current efforts are focused on approaches to reliably diagnosis and predict specific outcomes in systemic autoimmune rheumatic disease (SARDs) and antiphospholipid syndrome (APS). She is also actively involved in collaborative initiatives to harmonize and standardize serologic tests commonly used for autoimmune disease assessment.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: autoimmunity, inflammation, diagnosis, management, biomarkers
Email: anne.tebo@aruplab.com
Dimitri Tränkner, PhD
Title: Research Assistant Professor - Biology
Dr. Tränkner develops and applies genetics, optogenetics, and quantitative behavior assays to explore the cellular and molecular basis of psychological and mental disorders using the mouse as a model system. He currently focuses on the causal link between defective immune cells and sex-linked anxiety.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: anxiety, microglia, hormones, optogenetics, cognitive defects, mouse models
Email: dtrankner@genetics.utah.edu
Cornelia Ulrich, PhD
Title: Professor - Population Health Sciences
The Ulrich group works on colorectal cancer prevention, biomarkers
3i Bridge/Pillar: Cancer
Keywords: colorectal cancer, inflammation, aspirin, metabolomics, microbiome, adipose tissue, epidemiology, prognosis
Email: neli.ulrich@hci.utah.edu
John Valentine, MD
Title: Professor - Internal Medicine (Gastroenterology)
Interests include clinical and translational aspects of inflammatory bowel disease (ulcerative colitis and Crohn's disease) as well as other autoimmune and inflammatory disorders of the intestine. Projects include clinical trials and biomarker development, oncogenesis related to chronic inflammation.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: Crohn's disease, ulcerative colitis, intestinal inflammation
Email: john.valentine@hsc.utah.edu
Matthew VanBrocklin, PhD
Title: Associate Professor - Surgery
We have developed novel picornaviruses that preferentially target tumor cells and are assessing their ability to promote host anti-tumor immunity. We are assessing local and systemic factors that contribute to viral/tumor response and resistance in order to improve therapeutic strategies for multiple human cancers.
3i Bridge/Pillar: Cancer
Keywords: immunotherapy, oncolytic, virus, checkpoint, cancer, B7-H3
K-T Varley, PhD
Title: Assistant Professor - Oncological Sciences
The Varley Lab uses genomics to discover biomarkers and pathways associated with prognosis in breast cancer patients. We have found that cancer cells can express an immune pathway that induces an anti-tumor immune response. We are developing a biomarker test and immunotherapy strategies to harness this discovery in order to improve patient care.
3i Bridge/Pillar: Cancer
Keywords: cancer, genomics, immunotherapy
Email: K-T.Varley@hci.utah.edu
Michael Varner, MD
Title: Professor - Obstetrics/Gynecology
I have been facilitating clinical trials in women’s health – mainly obstetrics – for at the past 30 years.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: clinical trials, pregnancy, obstetrics and gynecology, women’s long-term health, fetal origins of disease
Email: michael.varner@hsc.utah.edu
Alessandro Venosa, PharmD, PhD
Title: Assistant Professor - Pharmacology and Toxicology
The Venosa Laboratory utilizes a multidisciplinary approach to study epithelial-immune cell crosstalk during the pathogenesis of pulmonary injury and fibrosis. The lab is particularly interested in studying the impact of air pollution exposure (i.e., ozone, particulate matter, wildfire smoke) on dysfunctional/susceptible lung epithelium (genetic mutations and ageing). To address this scientific question, we combine a novel murine model of lung injury and fibrosis initiated by a missense mutation in the pulmonary epithelial cell specific Surfactant Protein-C, with immune cell lineage tracing (see related publications https://www.ncbi.nlm.nih.gov/pubmed/29920187; https://www.ncbi.nlm.nih.gov/pubmed/30910861).
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: air pollution, epithelial-immune crosstalk, fibrosis, acute lung injury, genetic susceptibility
Monica Vetter, PhD
Title: Professor - Neurobiology and Anatomy
Microglia are dynamic remodelers of the central nervous system in both health and disease. Our research is focused on understanding the roles of microglia during
3i Bridge/Pillar: Neuroscience
Keywords: microglia, development, neurodegeneration, retina
Email: monica.vetter@neuro.utah.edu
Jessica Walsh, MD
Title: Assistant Professor - Internal Medicine (Rheumatology)
The Utah Spondyloarthritis Program integrates patient care and clinical research, with the goal of optimizing patient outcomes with early detection and treatment of spondyloarthritis and psoriatic arthritis.
3i Bridge/Pillar: Immune Deficiency/Dysregulation
Keywords: spondyloarthritis, psoriatic arthritis, ankylosing spondylitis, epidemiology, registries
Email: Jessica.Walsh@hsc.utah.edu
Diane Ward, PhD
Title: Research Associate Professor - Pathology
My research has focused on two major areas. First, I study membrane trafficking specifically looking at vesicle formation and molecules involved in endocytic/secretory vesicle homeostasis. My lab, in collaboration with Dr. Ryan O’Connell (Pathology), has focused on identifying the mechanisms that regulate exosome formation, release
3i Bridge/Pillar: Diabetes/Metabolism
Keywords: iron, mitochondria, lipids, Fe-S cluster, lysosome, erythroid development
Janis Weis, PhD
Title: Professor - Pathology
My laboratory studies the inflammatory pathways involved in the development of Lyme arthritis, a condition arising from infection with the
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Lyme arthritis, Borrelia burgdorferi, genetics, inflammatory pathways
Email: janis.weis@path.utah.edu
Andrew Weyrich, PhD
Title: Professor - Internal Medicine (Pulmonary)
Our laboratory investigates molecular mechanisms that regulate cell/cell interactions, cell signaling, and gene expression in the inflammatory and hemostatic systems, and how these events become dysregulated in human diseases.
3i Bridge/Pillar: Cardiovascular
Keywords: inflammation, gene expression, cell signaling
Email: andy.weyrich@utah.edu
Melodie Weller, PhD
Title: Assistant Professor - Dentistry
The Weller Lab studies viral profiles associated with the development and progression of Sjogren’s Syndrome and Sjogren’s Syndrome-associated Non-Hodgkin Lymphoma. Our primary aims are to identify how viruses are able to contribute to autoimmunity and, most importantly, how patients are being exposed to these pathogens. We are also working on saliva-based diagnostics to detect exposure to pathogens associated with Sjogren’s syndrome and other chronic diseases.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: Sjogren's Syndrome, virus, infection
Email: Melodie.Weller@hsc.utah.edu
Alana Welm, PhD
Title: Professor - Oncological Sciences
We investigate breast cancer metastasis and how the tumor microenvironment, such as the host immune system, facilitates metastatic outgrowth. We utilize a number of in vivo models, including patient-derived models, to discover new mechanisms and test new therapies.
3i Bridge/Pillars: Cancer
Keywords: breast cancer, metastasis, tumor microenvironment, tumor immunology
Email: Alana.Welm@hci.utah.edu
Karen Wilcox, PhD
Title: Professor - Pharmacology and Toxicology
Dr. Wilcox's areas of research interests include basic mechanisms of pharmacoresistant epilepsy, the role of inflammation in circuit function, seizure generation, and epileptogenesis, and the mechanism of action of anti-seizure drugs.
3i Bridge/Pillar: Neuroscience
Keywords: neuroinflammation, epilepsy, antiseizure drug development, glial cells
Email: karen.wilcox@hsc.utah.edu
Dustin Williams, PhD
Title: Research Assistant Professor - Orthopaedics
Our research is focused on developing therapies that target bacterial biofilms, which are highly tolerant to traditional antibiotics and contribute to difficulties in treating chronic wounds, surgical sites, orthopedic prostheses, diabetic foot ulcers
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: biofilm, antimicrobial, infection, bone, heterotopic ossification, models
Email: dustin.williams@utah.edu
Matt Williams, PhD
Title: Associate Professor - Pathology
Our research group seeks to understand the fate decisions that control the differentiation of T cells responding to infections and tumors. We are particularly focused on unraveling the mechanisms underlying the formation of long-lived memory T cells.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: immunological memory, T cell differentiation, anti-tumor immunity
Jaclyn Winter, PhD
Title: Assistant Professor - Medicinal Chemistry
Research in my lab focuses on natural products isolation and the bioengineering of natural product pathways for drug discovery and development. We use fungi and bacteria as resources for the discovery of new therapeutic agents and produce new chemical entities for biological activity testing by characterizing and manipulating the mechanisms that nature uses for assembling small molecules.
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: natural products biosynthesis, drug discovery, microbial communication, antibiotics, bioengineering, combinatorial biosynthesis
Email: Jaclyn.Winter@utah.edu
Carl Wittwer, MD, PhD
Title: Professor - Pathology
Method and instrument development for molecular diagnostics. Rapid cycle and extreme PCR (down to 15 s). High resolution and high speed melting analysis (down to 4 s).
3i Bridge/Pillar: Host-Microbe Interactions
Keywords: molecular methods, high resolution melting analysis, extreme PCR
Email: u0029724@utah.edu
Brandi Wynne, PhD
Title: Assistant Professor - Internal Medicine (Nephrology)
3i Bridge/Pillar:
Keywords:
Email: Brandi.Wynne@hsc.utah.edu
Mark Yandall, PhD
Title: Professor - Human Genetics
The Yandell group develops computational algorithms and software tools to analyze
3i Bridge/Pillars: Host-Microbe Interactions
Keywords: genomics, data science, software
Email: myandell@genetics.utah.edu
Christian Con Yost, MD
Title: Associate Professor - Pediatrics (Neonatology)
My research focuses on regulatory pathways governing inflammation in newborn infants, particularly those born prematurely, who are predisposed to inflammatory tissue damage as part of the pathogenesis for neonatal chronic lung disease, sepsis, and necrotizing enterocolitis. I recently discovered a novel endogenous peptide inhibitor of Neutrophil Extracellular Trap “NET” formation isolated from the umbilical cord blood of newborn infants. I am NIH funded to explore the role of this NET-inhibitory peptide in neonatal sepsis.
3i Bridge/Pillars: Immune Deficiency/Dysregulation
Keywords: neutrophil, neutrophil extracellular trap, NET, sepsis, newborn infant
Email: christian.yost@u2m2.utah.edu
Arabella Young, PhD
Title: Assistant Professor, Pathology
I am currently working on a tumor immunity/immune metabolism project: studying how endocrine immune related adverse events alter metabolic pathways and how that leads to better survival outcomes to cancer immunotherapies.
3i Bridge/Pillars: Immunity Pillar
Keywords: Immune-Related Adverse Events, Autoimmunity
Email: arabella.young@hci.utah.edu
Zemin Zhou, PhD
Title: Research Assistant Professor - Pathology
My research focuses on the molecular mechanism and regulation of antigen processing and presentation that involved in autoimmunity and infectious diseases. I am also interested in mechanisms involved in quality control of epitope presentation in adaptive immunity and immunological tolerance.
3i Bridge/Pillars: Immune Deficiency/Dysregulation
Keywords: MHC, HLA, Antigen processing, GILT, T cells, Autoimmunity
Email: Zemin.zhou@path.utah.edu
Guy Zimmerman, MD
Title: Professor - Internal Medicine (Pulmonary)
Our research group studies
3i Bridge/Pillar: Cardiovascular
Keywords: inflammation, NET, hemostasis, host responses to infection
Email: guy.zimmerman@u2m2.utah.edu