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The CQCI Preclinical Imaging program provides state-of-the-art quantitative imaging to support characterization of novel HCI rodent models as well as testing of novel therapeutic agents in preclinical trials. This resource enables bi-directional translation between ongoing HCI basic science research and HCI clinical trials to advance the mission of delivering advanced precision medicine to cancer patients.

Recent Publications

Barrott JJ, Zhu JF, Smith-Fry K, Susko AM, Nollner D, Burrell LD, Pozner A, Capecchi MR, Yap JT, Cannon-Albright LA, Deng X, Jones KB (2017). The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis. Mol Cancer Res, 15(12), 1733-1740.

Karsy M, Gillespie DL, Horn KP, Burrell LD, Yap JT, Jensen RL (2018). Correlation of Glioma Proliferation and Hypoxia by Luciferase, Magnetic Resonance, and Positron Emission Tomography Imaging. Methods Mol Biol, 1742301-320.

Wang LM, Wu Q, Kirk RA, Horn KP, Ebada Salem AH, Hoffman JM, Yap JT, Sonnen JA, Towner RA, Bozza FA, Rodrigues RS, Morton KA (2018). Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain. Am J Nucl Med Mol Imaging, 8(2), 86-99.

Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW 3rd, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M (2019). Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med, 25(4), 620-627.

Recent Presentations

Jeffrey Yap, Joshua Schiffman. Multi-modality preclinical imaging: From elephants to nanoparticles. Radiology and Imaging Sciences Symposium, University of Utah, March 31, 2018.

Jeffrey Yap. Maximizing Multimodality Synergy with SPECT/CT + PET/MRI. Mediso Industry Forum, September 13, 2018, Seattle, WA.

Jeffrey Yap, Brandon Buckway, Lance Burrell, Britney Beardmore, Zane Archibald, David Lum. PET/MRI imaging of Ewing sarcoma mouse model using 89Zr-labeled anti-CD99 antibody. World Molecular Imaging Congress, September 14, 2018, Seattle, WA.

Jeffrey Yap. Image Processing and Analysis Workflows for Maximizing Multimodality Synergy
with SPECT/CT + PET/MRI. inviCRO VivoQuant Users Meeting, September 26, 2018, Boston, MA.