What - Audience:
The end user, the client, the vendor, the retailer, marketing; anyone who is a stakeholder and should be considered in the design.
How - Technology:
Delivery platform, peripherals, available development hardware, software, and team skills, accessibility requirements
Pitch - Aesthetic:
What should the user feel as a result of the content? Art, sound, writing style, anything that affects the tone, mood, etc.
Iterate - Question:
The game mechanic, theory, or core question the end product, must answer