Mendoza Lab Publications
Mendoza Lab Publications
View all Mendoza M publications in the NIH PubMed database
Selected Publications:
ERK builds a population of short-lived nascent adhesions that produce persistent edge protrusion and cell migration
Andrew P. Shepherd, Keith R. Carney, Majid Rostami, Jakaria Shawon, Andrew Elliott, Shiela C. Samson, Sangyoon J. Han, and Michelle C. Mendoza. (2026) Proc Natl Acad Sci U S A. 123(25):e2525452123.
The LOK C-terminus is an IBAR-like domain that facilitates membrane binding and ezrin colocalization.
Jeriann R. Beiter Beiter, Dovydos Vasiliauskas, Gillian M. Hodge, Hannah E. Schneiderman, Monica C. Pillon, Sahithya S. Iyer, Michelle C. Mendoza, Andrew T. Lombardo, Gregory A. Voth. (2026) Biophys J. 125(11):2541-2554.
On the Mechanism of Ezrin Activation.
Dovydos Vasiliauskas, Jeriann Beiter, Sahithya S. Iyer, Anthony T. Lombardo, Michelle C. Mendoza, Gregory A. Voth. (2026) Biophys J 18:S0006-3495(26)00216-X
Mechanism of ERK-mediated Rho Activation and Stress Fiber Assembly for Cell Migration.
Akib M. Khan, Jakaria Shawon, Jared P. Bergman, Keith R. Carney, Michelle C. Mendoza. (2025) BioRxiv. doi: 2025.11.15.688645
Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin αvβ1 and FAK
Shiela C. Samson, Anthony Rojas, Rebecca G. Zitnay, Keith R. Carney, Wakeiyo Hettinga, Mary C. Shaelling, Delphine Sicard, Wei Zhang, Melissa Gilbert-Ross, Grace K. Dy, Michael J. Cavnar, Muhammad Furquan, Robert F. Browning Jr., Abdul R. Naqash, Bryan P. Schneider, Ahmad Tarhini, Daniel J. Tschumperlin, Alessandro Venosa, Adam I. Marcus, Lyska L. Emerson, Menjamin T. Spike, Beatrice S. Knudsen, Michelle C. Mendoza (2024) BioRxiv. 10.1101/2024.09.17.613509.
p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration.
Shiela C. Samson, Andrew Elliott, Brian D. Mueller, Yung Kim, Keith R. Carney, Jared P. Bergman, John Blenis, and Michelle C. Mendoza (2019)
Journal of Biological Chemistry 294(28):10846-10862
AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis.
David A. Kircher, Kirby A. Trombetti, Mark R. Silvis, Gennie L. Parkman, Grant M. Fischer, Stephanie N. Angel, Christopher M. Stehn, Sean C. Strain, Allie H. Grossmann, Keith L. Duffy, Kenneth M. Boucher, Martin McMahon, Michael A. Davies, Michelle C. Mendoza, Matthew W. VanBrocklin and Sheri L. Holmen (2019)
Mol Cancer Res. MCR-18-1372.
ERK Reinforces Actin Polymerization to Power Persistent Edge Protrusion during Motility.
Michelle C. Mendoza*, Marco Vilela*, Jesus E. Juarez, John Blenis, and Gaudenz Danuser (2015) Science Signaling 8:ra47
AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve.
E. Emrah Er, Michelle C. Mendoza, Ashley M. Mackey, Lucia E. Rameh, and John Blenis (2013) Science Signaling 6:ra34
Phosphoregulation of the WAVE Regulatory Complex and Signal Integration.
Michelle C. Mendoza (2013) Seminars in Cell and Developmental Biology 24:272-9
Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal-like Changes via c-MET/Extracellular Signal-Regulated Kinase (ERK) signaling.
Wenjuan Zhang, Michelle C. Mendoza, Xiaolei Pei, Didem Ilter, Sarah J. Mahoney, Yingmei Zhang, Dalong Ma, John Blenis, and Ying Wang (2012) Journal of Biological Chemistry 287:11850-8
Quantitative Fluorescent Speckle Microscopy (QFSM) to Measure Actin Dynamics.
Michelle C. Mendoza, Sebastien Besson, and Gaudenz Danuser (2012) Current Protocols in Cytometry 62:2.18.1-2.18.25
ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex.
Michelle C. Mendoza, E. Emrah Er*, Wenjuan Zhang*, Bryan A. Baliff, Hunter L. Elliott, Gaudenz Danuser, and John Blenis (2011) Molecular Cell 41:661-71
The Ras-ERK and PI3K-mTOR Pathways: Cross-talk and Compensation.
Michelle C. Mendoza, E. Emrah Er, and John Blenis (2011) Trends in Biomedical Sciences 36:320-8 (2011).
ERK-MAPK Signaling in the Cytoplasm.
Michelle C. Mendoza, E. Emrah Er, and John Blenis (2010) Methods in Molecular Biology 661:185-203
p90 Ribosomal S6 Kinase and p70 Ribosomal S6 Kinase Link Phosphorylation of the Eukaryotic Chaperonin containing TCP-1 to Growth Factor, Insulin, and Nutrient Signaling.
Yuki Abe, Sang-Oh Yoon, Kazuishi Kubota, Michelle C. Mendoza, Steven P. Gygi, and John Blenis (2009) Journal of Biological Chemistry 284:14939-48
Affiliations
- Department of Oncological Sciences
- Department of Biomedical Engineering
- Cancer Biology and Microenvironment Program
- Lung Center of Excellence
- Computational Oncology Research Initiative
- Molecular Biology Graduate Program
Collaborations
Mechanobiology: The Mendoza lab has a funded collaboration with the Weiss lab in the Biomedical Engineering department. This collaboration applies computational modeling and experimental stretching of lung tissue to understand the biomechanical signals involved in lung tumor growth.
Pollution and lung cancer: The Mendoza has lab a funded collaboration with Drs. Judy Ou and Chen Chen in Population Health Sciences to understand and target the cancer-promoting signals in particulate matter pollution.
Pathology: Support is also provided by Dr. Lyska Emerson in the Department of Pathology.