CBI Mass Spectrometry
CBI Mass Spectrometry
The Cancer Bioinformatics (CBI) Shared Resource offers mass spectrometry analysis services to help you gain biological insights from proteomic, metabolomic, and lipidomic data. We work with data generated by your lab, through the Proteomics and Metabolomics Cores, or from publicly available datasets.
Our team provides practical guidance on experimental design and data analysis to ensure accurate and reproducible results, whether you are planning targeted panels or broader discovery studies.
Experimental Design & Capabilities
We assist with both global profiling and targeted analyses. This includes planning experiments to measure overall abundance differences, setting up targeted panels for lipid or protein profiling, and profiling post-translational modifications (e.g., phosphorylation) to track changes in cellular signaling. The data are produced using advanced mass spectrometry systems that support data-dependent and data-independent acquisition modes. We apply best practices in data analysis to ensure your data are processed accurately.
Data Processing & Analysis Pipelines
Our analysis pipelines are designed to produce accurate and reproducible results. The workflow typically includes:
Data Preprocessing
Filtering, aligning spectral data, and normalizing to account for variability between runs.
Reporting
Generating detailed reports that include instrument performance, identification statistics, and quantitative results.
Pathway Enrichment
We can generate pathway enrichment reports that map significant changes in proteins, metabolites, or lipids onto curated metabolic and signaling pathways. These reports help identify the biological pathways affected by your experimental conditions.
For more information or to schedule a consultation, please submit a CBI help request.
Contact
Cancer Bioinformatics Director
David Nix, PhD
david.nix@hci.utah.edu
801-901-0649
Cancer Bioinformatics Associate Director
Timothy Parnell, PhD
timothy.parnell@hci.utah.edu
801-587-4312
Governance
HCI Senior Director Oversight
AC Tan, PhD
Shared Resource Advisory Committee Chair
Sean Tavtigian, PhD
Shared Resource Advisory Committee Members
Richard Clark, PhD
Sumati Gupta, MD
Robert Judson-Torres, PhD
Philip Moos, PhD
Andrew Post, MD, PhD
Melissa Reeves, PhD