- itBioPath Tracking System: The Biorepository uses the Integrative Transdisciplinary Biospecimen and Pathology Annotation Translational Health (itBioPath) to track all biospecimen activities from the patient consent to distribution. The Biorepository accreditation from the College of American Pathologists (CAP) ensures quality biospecimens by implementing and monitoring best practices thus improving research outcomes. The itBioPath system links to important clinical and pathological databases:
- Enterprise Data Warehouse (clinical records link; pathology, medicine and radiology)
- Oncology and Tumor Registry (cancer stage, outcomes, vital statistics)
- Cancer Clinical Research-CCR (subject registry, cohort studies, medical events, clinical pathology)
- Utah Population Database (genealogy, birth and death certificates)
- Genomix (molecular data)
- Project Registration: This required registration reserves biospecimens for specific projects as defined by the investigator or disease group. The Biorepository manages these registrations using the itBioPath tracking system.
- HCI Centralized Protocol: Investigators may use the centralized protocol, Molecular Classifications of Cancer (IRB# 10924), to procure, process and store biospecimens for cancer research.
- Project Coordination: We provide research team meetings and training sessions to define the key procurement activities for each staff member involved in the process.
- Informed Patient Consent: The Biorepository coordinators provide consent training to the clinic and surgery staff. They are also available to assist consenting patients as needed. Written informed consent from each donor is in accordance with the Department of Health and Human Services (HHS) regulations.
- Consent Management: Consents are validated, uploaded, and linked to the biospecimen collection events using the itBioPath tracking system while following HIPAA regulations and maintaining protected health information.
- Blood and Body Fluid Procurement, Processing and Storage: Project specific blood collection kits are prepared and stocked in the clinic and surgery areas. Blood and body fluids are procured, de-identified, processed, stored, and assigned to a registered project using the itBioPath tracking system.
- Tissue Procurement, Processing and Storage: We prepare tissue collection kits before the surgery. We transport tissues from the operating rooms to pathology. Surplus tissue is verified for research after the clinical diagnosis. We then de-identify, process, store, and assign the tissues to a registered project using the itBioPath tracking system.
- Biospecimen Distribution: Blood, body fluids, tissues, and their derivatives stored in the Biorepository are available upon request. Tissues distributed for research are confirmed by the Biorepository or collaborating pathologist prior to release. Permissions to release specimens may require investigator or group approval.
|Storage/Transport Preps||Temperature Ranges
(Ambient, 40C, -200C, -800C, -1350C)
|Cryopreserve, DMSO or Glycerol||RNAprotect Cell Reagent|
|Formalin, 10% NBF to Histology (FFPE)||RPMI|