Gertz Lab

Understanding Transcription Factors

The inappropriate expression of genes is a common defect across different types of cancer. Transcription factors (TF), which orchestrate gene expression patterns by interacting with specific loci throughout the genome, play a key role in the growth and development of tumors. Our research goal is to understand how transcription factors choose their genomic binding sites, how binding events lead to gene expression changes, and how the actions of transcription factors are altered in cancer.

To determine the roles that transcription factors play in gene regulation, we develop and apply experimental methods that take advantage of next-generation sequencing to create high-resolution maps of gene regulatory networks. We also utilize and create computational approaches to take full advantage of these rich genomic datasets.

News & Blog

Researchers Discover a Key Protein in Endometrial Cancer Growth
Feb 11, 2020

Researchers Discover a Key Protein in Endometrial Cancer Growth

The hormone estrogen plays many critical roles in men and women, in both healthy tissues and in cancer. In breast and gynecologic cancers, estrogen sends signals to tumors instructing the cancer cells to grow out of control. . In endometrial cancer, which arises in the lining of the uterus, estrogen is known to play a critical role in tumor development, yet many insights from how it affects breast cancer do not apply to endometrial cancer. New research from HCI Researchers outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments. ... Read More

Letter of Hope from the Gertz Lab
Jun 11, 2018

Letter of Hope from the Gertz Lab

It is patients like you, your loved ones, and Dr. Gertz's parents who keep us motivated and excited to find ways to help in the fight against this terrible disease. We appreciate everything you do as patients—like donating samples and participating in clinical trials—and we want you to know that we are doing everything we can to help patients with breast and uterine cancer.... Read More