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Selected Recent Publications

View current Beckerle MC publications in the National Institutes of Health PubMed website.

Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains.
Sun X, Phua DYZ, Axiotakis L Jr, Smith MA, Blankman E, Gong R, Cail RC, Espinosa de Los Reyes S, Beckerle MC, Waterman CM, Alushin GM.
Dev Cell. 2020 Nov 23;55(4):468-482.e7. doi: 10.1016/j.devcel.2020.09.022. Epub 2020 Oct 14.PMID: 33058779

Mechanical stress triggers nuclear remodeling and the formation of Transmembrane Actin Nuclear lines with associated Nuclear Pore Complexes.
Hoffman LM, Smith MA, Jensen CC, Yoshigi M, Blankman E, Ullman K, Beckerle MC. (2020).
Mol Biol Cell. 2020 Jan 22:mbcE19010027

Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Pishas KI, Drenberg CD, Taslim C, Theisen ER, Johnson KM, Saund RS, Pop IL, Crompton BD, Lawlor ER, Tirode F, Mora J, Delattre O, Beckerle MC, Callen DF, Sharma S, Lessnick SL.
Mol Cancer Ther. 2018 Sep;17(9):1902-1916. doi: 10.1158/1535-7163.MCT-18-0373. Epub 2018 Jul 11.

Mechanical signals activate p38 MPAK pathway-dependent reinforcement of actin via mechanosensitive HspB1.
Hoffman L, Jensen CJ, Yoshigi M, Beckerle MC (2017)
Mol Biol Cell e17020087

The actin regulator zyxin reinforces airway smooth muscle and accumlates in airways of fatal asthmatics.
Rosner SR, Pascoe CD, Blankman E, Jensen CJ, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park J, Beckerle MC, Pare PD, Fredberg JJ, Smith MA (2017)
PLOS One e0171728

Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.
Piccolo SR, Hoffman LM, Conner T, Shrestha G, Cohen AL, Marks JR, Neumayer LA, Agarwal CA, Beckerle MC, Andrulis IL, Spira AE, Moos PJ, Buys SS, Johnson WE, Bild AH (2016) 12:860
Mol Biol Cell 25:2695-709

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.
Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC (2014)
Mol Biol Cell 25:2695-709

A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton.
Stachowiak MR, Smith MA, Blankman E, Chapin LM, Balcioglu HE, Wang S, Beckerle MC, O'Shaughnessy B (2014)
PNaS 111:17528-33

Teaching corporate in college.
Valantine HA, Beckerle MC, Reed KL, Towner D, Zahniser NR (2014)
Mol Biol Cell 25:2695-709

LIM proteins in actin cytoskeleton mechanoresponse.
MA Smith, LM Hoffman, and MC Beckerle
Trends Cell Biol (2014)

Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers.
Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT (2014)
Cell Mol Bioeng 7: 73–85

Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth.
Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick SL (2014)
Clin Cancer Res 20:4584-97

Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants.
Pronovost SM, Beckerle MC, Kadrmas JL (2013)
PLoS Genet e1003406

Mary Beckerle, PhD

CEO, Huntsman Cancer Institute at the University of Utah

Reagent and Protocol Requests

To request reagents or protocols, contact:

Greg Alushin
The Rockefeller University