Huntsman Cancer Institute melanoma researchers have generated the first “atlas” of where human melanocytes are located in the body. In analyzing the atlas data, the team discovered different types of melanocytes, including what looks to be the cell of origin for an understudied subtype called acral melanoma, which mostly affects people of color.... Read More
About the Center
Melanoma is a type of cancer that forms in cells called melanocytes. It usually forms in skin, but can also form in other tissues such as the eyes or intestines. Exposure to ultraviolet radiation from the sun or tanning beds can raise the risk of melanoma of the skin. Members of the Melanoma Center do research to improve understanding and management of skin cancers. The center has these broad goals:
- Improve melanoma treatment
- Develop immune system therapies to treat it
- Create targeted therapies against proteins involved in the disease’s spread to other areas
- Identify new genes involved in melanoma susceptibility
- Develop strategies to prevent the disease
- Develop animal models of melanoma
A Sample of Current Projects
- Investigating aspirin as a UV-protectanct and potential melanoma prevention agent in subjects at high-risk for melanoma.
- Studying mechanisms of combination immunotherapy plus oncolytic virus-based therapy for melanoma.
- Examining genes that regulate development of melanoma brain metastases.
- Developing alternating dosing regimens to forestall the onset of drug resistance in patients with advanced BRAF-mutated melanoma.
Max Rosett faced melanoma as a young adult and a decade later, he is cancer free. He describes how he felt after being diagnosed, the outstanding treatment he received at Huntsman Cancer Institute and the revolutionary immunotherapy clinical trials that helped save his life.... Read More
Researchers at Huntsman Cancer Institute have found critical new insights into how cells defend against melanoma. In a report published in Nature Communications, the team describes how an enzyme called nicotinamide phosphoribosyltransferase, or NAMPT, initiates antitumor activity. The researchers suggest that new therapies strengthening this pathway in immune cells could be the foundation for more effective treatments against melanoma.... Read More