About the Center

Melanoma is a type of cancer that forms in cells called melanocytes. It usually forms in skin, but can also form in other tissues such as the eyes or intestines. Exposure to ultraviolet radiation from the sun or tanning beds can raise the risk of melanoma of the skin. Members of the Melanoma Center do research to improve understanding and management of skin cancers. The center has these broad goals:

  • Improve melanoma treatment
  • Develop immune system therapies to treat it
  • Create targeted therapies against proteins involved in the disease’s spread to other areas
  • Identify new genes involved in melanoma susceptibility
  • Develop strategies to prevent the disease
  • Develop animal models of melanoma

Melanoma Research Labs

A Sample of Current Projects

  • Investigating aspirin as a UV-protectanct and potential melanoma prevention agent in subjects at high-risk for melanoma.

  • Studying mechanisms of combination immunotherapy plus oncolytic virus-based therapy for melanoma.
  • Examining genes that regulate development of melanoma brain metastases.
  • Developing alternating dosing regimens to forestall the onset of drug resistance in patients with advanced BRAF-mutated melanoma.


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Melanoma Center Co-leader

Douglas Grossman, PhD, MD
Professor of Dermatology
Cancer Center Bio

Melanoma Center Co-leader

Sheri L. Holmen, PhD
Professor in the Department of Surgery
Cancer Center Bio