New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination. This study illuminates genetic understanding of acute lymphoblastic leukemia in children with the worst outcomes, including relapse and/or death.... Read More
Working to Understand Who Develops Cancer and Why
The Schiffman Lab studies pediatric hereditary cancer syndromes, with a special interest in genetic susceptibility to childhood cancers. Our research investigates molecular changes in childhood cancers, as well as the germline genetic variation that gives rise to childhood tumors. It is our goal to find out who gets cancer and why, so that we can develop ways to better predict, prevent, and treat cancer in the clinic.
All of our studies include the perspective of evolutionary (Darwinian) medicine, with a focus on comparative oncology to identify universal drivers of cancer risk and development. By examining the genetics of cancer in our animal relatives alongside our own, we offer a dynamic and creative approach to translational genomics. Working with collaborators from all over the country and the world, we’re able to study cancer in people, dogs, and elephants. This transdisciplinary approach continues to yield new and exciting results.
Areas of Study
- p53 and Li-Fraumeni Syndrome
- Elephant p53
- What Is Ewing Sarcoma?
- Genetic Predispositions for Ewing Sarcoma (Project GenESis)
- The Genetics of Ewing Sarcoma Tumors
Cancer in the Population
- Cancer Genetics Study
- Pediatric Biobank
News & Blog
Huntsman Cancer Institute recognizes new and renewed endowed chairs, along with the distinguished professorship of faculty. Endowed chairs play an important role in creating a partnership between donors and researchers. Distinguished professors are recognized for academic achievements and dedication to teaching. ... Read More
Jenny Gray was expecting a baby boy when she was diagnosed with osteosarcoma. Her leg was amputated and her son was induced at 35 weeks so she could begin chemotherapy. Jenny learned she and her son have Li-Fraumeni syndrome (LFS), which significantly raises the risk of cancer. Jenny and two other women talk about living with LFS and HCI experts discuss what to do if you have it.... Read More
When Kiera Jorgensen was diagnosed with cancer at the age of 19, she fought not only sarcoma, but also a mystery that had loomed over her family for generations. Now years out of treatment, Kiera has answers and is conducting research to help families like hers better understand a rare genetic mutation.... Read More
September is Childhood Cancer Awareness Month, and Kneaders Bakery and Cafe is encouraging customers to join them in their unique campaign to fight childhood cancer, one delicious cookie at a time!... Read More
Starting September 12, you can buy these delicious Elephant-shaped sugar cookies, dipped in white chocolate, with sprinkles at any of the 9 Kneaders locations in Colorado. 100% of sales from each cookie sale goes to benefit Dr. Josh Schiffman's Childhood Cancer Research at the Huntsman Cancer Institute.... Read More