Chandrasekharan Lab

Studying Histone & Non-Histone Protein Modifications

The Chandrasekharan Lab’s focus is to understand the regulation and functions of histone and non-histone protein modifications during transcription, replication, recombination, and repair. Our current interest is to uncover the molecular mechanisms involved in the crosstalk between histone H2B ubiquitination and histone H3 lysine-4 & lysine-79 methylation.

Enzymes and regulatory factors involved in this evolutionarily conserved trans-histone crosstalk play important roles in normal development and in cancer-related processes. We use yeast and mammalian model systems, and employ both classical and modern, biochemical, biophysical, genetic and genomics-based approaches to understand various aspects of epigenetics and chromatin biology.

News & Blog

4
Research
Jun 21, 2016

Manuscript published!

Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription... Read More

Research
Oct 08, 2015

Manuscript accepted!

Interaction of the Jhd2 H3K4 demethylase with chromatin is controlled by histone H2A surfaces and restricted by H2B ubiquitination.... Read More

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Mahesh B. Chandrasekharan, PhD
Principal Investigator
Email
Cancer Center Bio

Contact Us

Chandrasekharan Lab
Huntsman Cancer Institute
2000 Circle of Hope, Rm 4343
Salt Lake City, UT 84112

Phone: 801-213-4220
Fax: 801-585-0900
Email: mahesh.chandrasekharan@hci.utah.edu

Callee LePlant
Administrative Assistant
Phone: 801-585-3599