Current Chandrasekharan MB publications in the National Institutes of Health PubMed website

Selected Publications

Structure and functional determinants of Rad6-Bre1 subunits in the histone H2B ubiquitin-conjugating complex. Shukla, PK, Bissell, JE, Kumar, S, Pokhrel, S, Palani, S, Radmall, KS, Obidi, O, Parnell, TJ, Brasch, J., Shrieve, DC, Chandrasekharan, MB. (2023)

Nucleic Acids Res 51, 2117-2136

HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia. 
Tharkar-Promod S, Johnson DP, Bennett SE, Dennis EM, Banowsky BG, Jones SS, Shearstone JR, Quayle SN, Min C, Jarpe M, Mosbruger T, Pomicter AD, Miles RR, Chen WY, Bhalla KN, Zweidler-McKay PA, Shrieve DC, Deininger MW, Chandrasekharan MB, Bhaskara S. 
Leukemia. 2018 32(1):49-60.

Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription.  
Ramakrishnan S, Pokhrel S, Palani S, Pflueger C, Parnell TJ, Cairns BR, Bhaskara S, Chandrasekharan MB. 
Nat. Commun. 7:11949 doi: 10.1038/ncomms11949 (2016).

Interaction of the Jhd2 H3K4 demethylase with chromatin is controlled by histone H2A surfaces and restricted by H2B ubiquitination. 
Huang F, Ramakrishnan S, Pokhrel D, Pflueger C, Parnell TJ, Kasten MM, Currie SL, Bhachech N, Horikoshi M, Graves BJ, Cairns BR, Bhaskara S, Chandrasekharan MB. 
J. Biol. Chem. 2015 Nov 27; 290(48): 28760–77

HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma. 
Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S.  
Oncotarget. 2015 Mar 10;6(7):4863-87.  
PMID: 25605023 Free Article

Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression. 
Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB. 
Epigenetics Chromatin. 2013 Aug 15;6(1):27.

Hdac3 is essential for the maintenance of chromatin structure and genome stability. 
Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW. 
Cancer Cell. 2010 Nov 16;18(5):436-47.

Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. 
Chandrasekharan MB, Huang F, Sun ZW. 
Epigenetics. 2010 Aug 16;5(6):460-8.

Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination. 
Chandrasekharan MB, Huang F, Chen YC, Sun ZW. 
Mol Cell Biol. 2010 Jul;30(13):3216-32.

Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. 
Chandrasekharan MB, Huang F, Sun ZW. 
Proc Natl Acad Sci USA. 2009 Sep 29;106(39):16686-91.

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. 
Nakanishi S, Lee JS, Gardner KE, Gardner JM, Takahashi YH, Chandrasekharan MB, Sun ZW, Osley MA, Strahl BD, Jaspersen SL, Shilatifard A. 
J Cell Biol. 2009 Aug 10;186(3):371-7.