Current Chandrasekharan MB publications in the National Institutes of Health PubMed website
Selected Publications
Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae.
McCullough LL, Pham TH, Parnell TJ, Connell Z, Chandrasekharan MB, Stillman DJ, Formosa T.
Genetics. 2019 Mar;211(3):877-892.
HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.
Tharkar-Promod S, Johnson DP, Bennett SE, Dennis EM, Banowsky BG, Jones SS, Shearstone JR, Quayle SN, Min C, Jarpe M, Mosbruger T, Pomicter AD, Miles RR, Chen WY, Bhalla KN, Zweidler-McKay PA, Shrieve DC, Deininger MW, Chandrasekharan MB, Bhaskara S.
Leukemia. 2018 32(1):49-60.
A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.
Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP.
Elife. 16:6. pii: e28723 (2017)
Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription
Ramakrishnan S, Pokhrel S, Palani S, Pflueger C, Parnell TJ, Cairns BR, Bhaskara S, Chandrasekharan MB.
Nat. Commun. 7:11949 doi: 10.1038/ncomms11949 (2016).
Sumoylation regulates growth factor independence (GFI)-1 in transcriptional control and hematopoiesis.
Andrade D, Velinder M, Singer J, Maese L, Bareyan D, Nguyen H, Chandrasekharan MB, Lucente H, McClellan D, Jones D, Sharma S, Liu F, Engel ME.
Mol Cell Biol. 2016. pii: MCB.01001-15. [Epub ahead of print]
Interaction of the Jhd2 H3K4 demethylase with chromatin is controlled by histone H2A surfaces and restricted by H2B ubiquitination.
Huang F, Ramakrishnan S, Pokhrel D, Pflueger C, Parnell TJ, Kasten MM, Currie SL, Bhachech N, Horikoshi M, Graves BJ, Cairns BR, Bhaskara S, Chandrasekharan MB.
J. Biol. Chem. 2015 Nov 27; 290(48): 28760–77
HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma.
Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S.
Oncotarget. 2015 Mar 10;6(7):4863-87.
PMID: 25605023 Free Article
Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression.
Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB.
Epigenetics Chromatin. 2013 Aug 15;6(1):27.
Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors.
Chandrasekharan MB, Huang F, Sun ZW.
Methods. 2011 Jul;54(3):304-14. Review.
Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.
Joo HY, Jones A, Yang C, Zhai L, Smith AD 4th, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C, Wang H.
J Biol Chem. 2011 Mar 4;286(9):7190-201.
Hdac3 is essential for the maintenance of chromatin structure and genome stability.
Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW.
Cancer Cell. 2010 Nov 16;18(5):436-47.
Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation.
Chandrasekharan MB, Huang F, Sun ZW.
Epigenetics. 2010 Aug 16;5(6):460-8.
The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation.
Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW.
J Biol Chem. 2010 Aug 6;285(32):24548-61.
Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination.
Chandrasekharan MB, Huang F, Chen YC, Sun ZW.
Mol Cell Biol. 2010 Jul;30(13):3216-32.
Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability.
Chandrasekharan MB, Huang F, Sun ZW.
Proc Natl Acad Sci USA. 2009 Sep 29;106(39):16686-91.
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.
Nakanishi S, Lee JS, Gardner KE, Gardner JM, Takahashi YH, Chandrasekharan MB, Sun ZW, Osley MA, Strahl BD, Jaspersen SL, Shilatifard A.
J Cell Biol. 2009 Aug 10;186(3):371-7.
Carcinogen-induced histone alteration in normal human mammary epithelial cells.
Bradley C, van der Meer R, Roodi N, Yan H, Chandrasekharan MB, Sun ZW, Mernaugh RL, Parl FF.
Carcinogenesis. 2007 Oct;28(10):2184-92.