Melanoma is the most serious form of skin cancer. According to the American Cancer Society, when melanoma is caught early, there’s a 5-year survival rate of about 97%. Once the cancer spreads to other organs, the survival rate drops to 15–20%.... Read More
Defining Critical Targets in Cancer Cells
Our lab is focused on defining critical targets in cancer cells that can become the focus for therapeutic intervention. Because of the high cost of developing new therapies, it is essential to first identify which genetic alterations can be productively targeted. We are concentrating our initial efforts on using a genetic approach in tumors that are refractory to conventional therapies including metastatic melanoma and glioblastoma. We plan to further validate these targets using pharmacological inhibitors of clinical importance.