Evason Lab Publications
Evason Lab Publications
View all Evason KJ publications in NIH PubMed
Selected publications related to Liver Development and Liver Tumorigenesis
VanSant-Webb C, Castro JC, Su AY, Hawkins K, Saxena A, Wright J, Smith R, Fragoso-García M, Chen YA, Barton C, Stubben C, O'Connell RM, Ducker GS, Evason KJ. MicroRNA-21 promotes dysregulated lipid metabolism and hepatocellular carcinoma. Dis Model Mech. 2026 Feb 1;19(2). doi: 10.1242/dmm.052583. Epub 2026 Mar 5. PubMed PMID: 41582686; PubMed Central PMCID: PMC12994464.
Nelson MC, O'Malley LC, Lee SH, Bauer KM, Ghazaryan A, Tang WW, VanSant-Webb C, Tran VB, Hernandez C, Battistone B, Thibeaux A, Round JL, Drummond MJ, Ekiz HA, Evason KJ, Voth WP, O'Connell RM. MicroRNA-146a Protects against Hepatocellular Carcinoma through Suppression of CCL5. Cancer Res Commun. 2026 Feb 1;6(2):359-373. doi: 10.1158/2767-9764.CRC-25-0474. Epub 2026 Jan 23. PubMed PMID: 41718085.
Gallop MR, Vieira RFL, Mower PD, Matsuzaki ET, Liou W, Smart FE, Roberts S, Evason KJ, Holland WL, Chaix A. A long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin secretion in mice. Sci Adv. 2025 Sep 19;11(38):eadx2752. doi: 10.1126/sciadv.adx2752. Epub 2025 Sep 19. PubMed PMID: 40971428; PubMed Central PMCID: PMC12448075.
Velasco-Silva JN, Wilkerson JL, Ramos D, Low HK, Bowman F, Evason KJ, Boudina S, Holland WL, Ducker GS. Loss of hepatic autophagy induces α-cell proliferation through impaired glutamine-dependent gluconeogenesis. Physiol Rep. 2025 May;13(10):e70381. doi: 10.14814/phy2.70381. PubMed PMID: 40420631; PubMed Central PMCID: PMC12106947.
selectAcuña-Pilarte K, Reichert EC, Green YS, Halberg LM, Golkowski M, Maguire KM, Mimche PN, Kamdem SD, Hu PA, Wright J, Ducker GS, Voth WP, O'Connell RM, McFarland SA, Egal ESA, Chaix A, Summers SA, Reelitz JW, Maschek JA, Cox JE, Evason KJ, Koh MY. HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-κB pathway. Hepatology. 2025 Aug 1;82(2):438-453. doi: 10.1097/HEP.0000000000001070. Epub 2024 Sep 10. PubMed PMID: 39255518; PubMed Central PMCID: PMC12266801.
Freeburg SH, Shwartz A, Kemény LV, Smith CJ, Weeks O, Miller BM, PenkoffLidbeck N, Fisher DE, Evason KJ, Goessling W. Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Rep. 2024 Jul 23;43(7):114393. doi: 10.1016/j.celrep.2024.114393. Epub 2024 Jun 28. PubMed PMID: 38944835; PubMed Central PMCID: PMC11708751.
VanSant-Webb C, Low HK, Kuramoto J, Stanley CE, Qiang H, Su AY, Ross AN, Cooper CG, Cox JE, Summers SA, Evason KJ, Ducker GS. Phospholipid isotope tracing suggests β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Aug;1869(6):159514. doi: 10.1016/j.bbalip.2024.159514. Epub 2024 May 23. PubMed PMID: 38795827; PubMed Central PMCID: PMC11864496.
Ong AJS, Bladen CE, Tigani TA, Karamalakis AP, Evason KJ, Brown KK, Cox AG. The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2217425120. doi: 10.1073/pnas.2217425120. Epub 2023 May 22. PubMed PMID: 37216554; PubMed Central PMCID: PMC10235939.
Leonard NB, Hale GL, Boylan KE, Ou Z, Zhang C, Kim R, Chandna S, Dong ZM, Evason KJ. Histologic features of allograft livers in patients treated for rejection before biopsy. Hum Pathol. 2023 May;135:11-21. doi: 10.1016/j.humpath.2023.02.005. Epub 2023 Feb 18. PubMed PMID: 36804507; PubMed Central PMCID: PMC10121875.
Bowman KER, Ahne L, O'Brien L, Vander Mause ER, Lu P, Wallis B, Evason KJ, Lim CS. p53-Bad* Fusion Gene Therapy Induces Apoptosis In Vitro and Reduces Zebrafish Tumor Burden in Hepatocellular Carcinoma. Mol Pharm. 2023 Jan 2;20(1):331-340. doi: 10.1021/acs.molpharmaceut.2c00665. Epub 2022 Dec 9. PubMed PMID: 36490361; PubMed Central PMCID: PMC10760808.
Ellis JL, Evason KJ, Zhang C, Fourman MN, Liu J, Ninov N, Delous M, Vanhollebeke B, Fiddes I, Otis JP, Houvras Y, Farber SA, Xu X, Lin X, Stainier DYR, Yin C. A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatol Commun. 2022 Nov;6(11):3083-3097. doi: 10.1002/hep4.2038. Epub 2022 Aug 26. PubMed PMID: 36017776; PubMed Central PMCID: PMC9592797.
Kalasekar SM, VanSant-Webb CH, Evason KJ. Intratumor Heterogeneity in Hepatocellular Carcinoma: Challenges and Opportunities. Cancers (Basel). 2021 Nov 3;13(21). doi: 10.3390/cancers13215524. Review. PubMed PMID: 34771685; PubMed Central PMCID: PMC8582820.
Kotiyal S, Evason KJ. Exploring the Interplay of Telomerase Reverse Transcriptase and β-Catenin in Hepatocellular Carcinoma. Cancers (Basel). 2021 Aug 20;13(16). doi: 10.3390/cancers13164202. Review. PubMed PMID: 34439356; PubMed Central PMCID: PMC8393605.
Kalasekar SM, Garrido-Laguna I, Evason KJ. Immune Checkpoint Inhibitors in Combinations for Hepatocellular Carcinoma. Hepatology. 2021 Jun;73(6):2591-2593. doi: 10.1002/hep.31706. Epub 2021 May 21. PubMed PMID: 33434363.
Pham DH, Kudira R, Xu L, Valencia CA, Ellis JL, Shi T, Evason KJ, Osuji I, Matuschek N, Pfuhler L, Mullen M, Mohanty SK, Husami A, Bull LN, Zhang K, Wali S, Yin C, Miethke A. Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms. Gastroenterology. 2021 Jul;161(1):287-300.e16. doi: 10.1053/j.gastro.2021.03.026. Epub 2021 Mar 23. PubMed PMID: 33771553; PubMed Central PMCID: PMC8238842.
Kotiyal S, Fulbright A, O'Brien LK, Evason KJ. Quantifying Liver Size in Larval Zebrafish Using Brightfield Microscopy. J Vis Exp. 2020 Feb 2;(156). doi: 10.3791/60744. PubMed PMID: 32065169; PubMed Central PMCID: PMC7590575.
Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J. Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Cell Metab. 2020 Feb 4;31(2):284-300.e7. doi: 10.1016/j.cmet.2019.11.002. Epub 2019 Dec 5. PubMed PMID: 31813825; PubMed Central PMCID: PMC7004878.
Kalasekar SM, Kotiyal S, Conley C, Phan C, Young A, Evason KJ. Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish. Biol Open. 2019 Oct 17;8(10). doi: 10.1242/bio.047829. PubMed PMID: 31575545; PubMed Central PMCID: PMC6826293.
Epithelial Inclusions in Gallbladder May Mimic Parasite Infection. Evason KJ, Swanson EA. Am J Clin Pathol (2019), 152 (3), 399-402.
Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humans. Dubey JP, Evason KJ, Walther Z, Parasitology (2019), 146 (7), 865-872.
Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W, Gastroenterology (2019), 156 (6), 1788-1804. e13.
Anti-inflammatory micro RNA-146a protects mice from diet-induced metabolic disease. Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, RoundJL, Drummond MJ, O'Connell RM, PLoS Genet (2019), 15 (2), e 1007970.
Epithelial Inclusions in Gallbladder May Mimic Parasite Infection: Histologic and Molecular Examination of Reported Cystoisospora belli Infection in Gallbladders of Immunocompetent Patients. Swanson EA, March JK, Clayton F, Couturier MR, Arcega R, Smith R, Evason KJ, Am J Surg Pathol (2018), 42 (10), 1346-1352.
Wnt/β-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating Notch activity.
So, J., Khaliq, M., Evason, K.J., Ninov, N., Martin, B.L., Stainier, D.Y.R., Shin D.
Hepatology (2017) doi:10.1002/hep.29752
MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. Anderton, B., Camarda, R., Balakrishnan, S., Balakrishnan, A., Kohnz, R.A., Lim, L., Evason, K.J., Momcilovic, O., Kruttwig, K., Huang, Q., Xu, G., Nomura, D.K., Goga, A.
EMBO Rep. (2017) 18:569-585
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.
Cox, A.G., Hwang, K.L., Brown, K.K., Evason, K.J., Beltz, S., Tsomides, A., O'Connor, K., Galli, G.G., Yimlamai, D., Chhangawala, S., Yuan, M., Lien, E.C., Wucherpfennig, J., Nissim, S., Minami, A., Cohen, D.E., Camargo, F.D., Asara, J.M., Houvras, Y., Stainier, D.Y., Goessling, W.
Nat Cell Biol. (2016) 18:886-96
Monocyte-dependent liver injury promotes carcinogenesis in an oncogene-specific manner.
Juric, V., Ruffell, B., Evason, K.J., Hu, J., Che, L., Wang, L., Chen, X., Bishop, J.M.
J Hepatol. (2016) pii:S0168-8278(15)00783-7
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
Evason, K.J., Francisco, M.T., Juric, V., Balakrishnan, S., Lopez Pazmino, M. del P., Gordan, J.D., Kakar, S., Spitsbergen, J., Goga, A. and Stainier, D.Y.
PLoS Genet. (2015) 11:e1005305
Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls.
Kelley, R.K., Magbanua, M.J., Butler, T.M., Collisson, E.A., Hwang, J., Sidiropoulos, N., Evason, K., McWhirter, R.M., Hameed, B., Wayne, E.M., Yao, F.Y., Venook, A.P., Park, J.W.
BMC Cancer (2015) 15:206
CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation.
Huskey, N.E., Guo, T., Evason, K.J., Momcilovic, O., Pardo, D., Creasman, K.J., Judson, R.L., Blelloch, R., Oakes, S.A., Hebrok, M., Goga, A.
Stem Cell Reports (2015) 4:374-89
Cases of Spontaneous Tumor Regression in Hepatobiliary Cancers: Implications for Immunotherapy?
Parks, A.L., McWhirter, R.M., Evason, K., Kelley, R.K.
J Gastrointest Cancer (2015) 46:161-65
The perivascular niche regulates breast tumour dormancy.
Ghajar, C.M., Peinado, H., Mori, H., Matei, I.R., Evason, K.J., Brazier, H., Almeida, D., Koller, A., Hajjar, K.A., Stainier, D.Y., Chen, E.I., Lyden, D., Bissell, M.J.
Nat Cell Biol. (2013) 15:807-17
Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification.
Balabaud, C., Al-Rabih, W.R., Chen, P.J., Evason, K., Ferrell, L., Hernandez-Prera, J.C., Huang, S.F., Longerich, T., Park, Y.N., Quaglia, A., Schirmacher, P., Sempoux, C., Thung, S.N., Torbenson, M., Wee, A., Yeh, M.M., Yeh, S.H., Le Bail, B., Zucman-Rossi, J., Bioulac-Sage, P.
Int J Hepatol. (2013) 268625
Hepatic stellate cells in liver development, regeneration, and cancer.
*Yin, C., *Evason, K.J., Asahina, K., Stainier, D.Y.
J Clin Invest. (2013) 23:1902-10 *Equal contributions
Atypical hepatocellular adenoma-like neoplasms with β-catenin. activation show cytogenetic alterations similar to well-differentiated hepatocellular carcinomas.
Evason, K.J., Grenert, J.P., Ferrell, L.D., Kakar, S.
Hum Pathol. (2013) 44:750-8
The bHLH transcription factor Hand2 marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver.
*Yin, C., *Evason, K.J., Maher, J.J., Stainier, D.Y.
Hepatology (2012) 56:1958-70 *Equal contributions
Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Cheung, I.D., Bagnat, M., Ma, T.P., Datta, A., Evason, K.J., Moore, J.C., Lawson, N.D., Mostov, K.E., Moens, C.B., Stainier, D.Y.
Dev Biol. (2012) 361:68-78
Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies.
Evason, K.J., Bove, K.E., Finegold, M.J., Knisely, A.S., Rhee, S., Rosenthal, P., Miethke, A.G., Karpen, S.J., Ferrell, L.D., Kim, G.E.
Am J Surg Pathol. (2011) 35:687-96
The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan.
Collins, J.J., Evason, K.J., Pickett, C.L., Schneider, D.L., and Kornfeld, K.
PLoS Genetics (2008) 4:e1000230
Valproic acid extends C. elegans lifespan.
*Evason, K.J., *Collins, J.J., Huang, C., Hughes, S., and Kornfeld, K.
Aging Cell (2008) 7:305-17 *Equal contributions
Genetic and Pharmacological Factors That Influence Reproductive Aging in Nematodes.
Hughes, S.E., Evason, K.J., Xiong, C., and Kornfeld, K.
PLoS Genetics (2007) 3:e25
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans.
Collins, J.J., Evason, K.J., and Kornfeld, K.
Experimental Gerontology (2006) 41:1032-9
Effects of anticonvulsant drugs on life span.
Kornfeld, K. and Evason, K.J.
Archives of Neurology (2006) 63:491-496
Anticonvulsant medications extend C. elegans lifespan.
Evason, K.J., Huang, C., Yamben, I., Covey, D.F., and Kornfeld, K.
Science (2005) 307:258-262
Misdirected vimentin messenger RNA alters cell morphology and motility.
Morris, E.J., Evason, K.J., Wiand, C., L’Ecuyer, T.J., and Fulton, A.B.
Journal of Cell Science (2000) 113:2433-43