Grant Funding

Source: 

National Cancer Institute (NCI)

Number

R21 CA150381

Project Title

Preliminary Evaluation of FDG-PET with anti-IGF-1R Targeted Therapy in GISTs.

PI

Jeffrey T. Yap, PhD

The major goals of this multi PI project are:

  1. To test the novel therapeutic anti-IGF1R tyrosine kinase inhibitor OSI-906 in the treatment of patients with advanced GIST; 
  2. To test the ability of FDG-PET to evaluate the metabolic response to OSI-906 using FDG-PET and determine if tumor metabolic response predicts anatomic response; and
  3. To correlate levels of insulin and IGF family members and their endogenous regulators to changes in normal tissues and tumor metabolic activity as measured by FDG-PET.  This is a subcontract to
  4. Fox Chase Cancer Center.

Source: 

SARC Sarcoma SPORE

Number

Project Title

Project 4: Development of quantitative imaging biomarkers for assessing response to sarcoma therapy.

PI

Jeffrey T. Yap, PhD

This project seeks to develop new imaging approaches using MRI and PET to non-invasively measure various aspects of tumor biology and pathophysiology in response to conventional and experimental chemotherapies.  This will enable a powerful set of tools to evaluate treatment efficacy and ultimately improve the development of new drugs and clinical management of sarcoma patients.  This is a subcontract to SARC.

Source: 

National Institute of Biomedical Imaging and Bioengineering (NIH)

Number

R21 EB013795-01A1

Project Title

Voxelwise analysis of imaging response to therapy in neuro-oncology.

PI

Jeffrey T. Yap, PhD

The major goal of this project is to develop more objective methods for evaluation of oncology brain FDG-PET images that can indicate changes anywhere in the brain and correct for the confounding effects induced by global and regional changes in normal brain metabolism. This is achieved by a voxelwise comparison between the pre-treatment and post-treatment 3D scans, preceded by spatial registration, segmentation and background adjustment, and followed by statistical significance thresholding. This is a subcontract to North Carolina State University

Current Funding for CQCI Faculty

Source: 

National Cancer Institute (NIH)

Number

1-R21 CA167795-01

Project Title

Multi-tracer PET Assessment of Response to Novel Targeted Chemotherapy

PI

John M. Hoffman, MD (Morton Co-PI)

Source: 

National Cancer Institute (NCI)

Number

2R01CA135556-05

Project Title

Multi-tracer PET Tumor Imaging

PI

Dan Kadrmas, PhD

Source:

National Cancer Institute (NCI)

Number

1-R21-CA128228-01

Project Title

FDG-PET/CT in the evaluation of persistent febrile neutropenia in cancer patients

PI

John M. Hoffman, MD

Source: 

National Institute of Biomedical Imaging and Bioengineering (NIH)

Number

5 R03 EB014454 02

Project Title

Optimized PET Reconstruction for Cancer Detection

PI

Dan J Kadrmas, PhD

Recent Funding for CQCI Faculty

Source: 

National Cancer Institute (NIH)

Number

1 R01 CA135556-01A1

Project Title

Multi-tracer PET Tumor Imaging

PI

Dan J Kadrmas, PhD

Source: 

National Institute of Biomedical Imaging and Bioengineering (NIH)

Number

2 R01 EB000177-05

Project Title

Dynamic MRI for Myocardial Perfusion and Viability

PI

Edward VR DiBella, PhD

Source: 

University of Utah Synergy Grant Program

Number

N/A

Project Title

Development of an Integrated Molecular Biomarker of Early Prediction of Therapeutic Response to Targeted Therapy in Stage IIIB/IV or Recurrent  Lung Cancer Patients using Imaging Assessments and Genomic Modeling

PI

John M. Hoffman, MD

Source: 

National Cancer Institute (NIH)

Number

R01 CA121003-01

Project Title

FDG PET in cancer-associated venothromboembolic disease

PI

Kathryn A. Morton, M.D.

Contact Us

Center for Quantitative Cancer Imaging Director
John M. Hoffman, MD
john.hoffman@hci.utah.edu
801-587-4064

Governance

HCI Senior Director Oversight
Cornelia Ulrich, MS, PhD

Faculty Advisory Committee Chair
David Goldgar, PhD

Faculty Advisory Committee Members
Lisa Aspinwall, PhD
Saundra Buys, MD
Matthew Firpo, PhD
Kimberly Kaphingst, PhD
Deborah Neklason, PhD
Erin Rothwell, MS, PhD
Joshua Schiffman, MD
Theresa Werner, MD