Huntsman Cancer Institute Spike Lab


View all Spike BT publications in the NIH PubMed Database

Selected Publications

Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer
Edward R. Polanco, Tarek E. Moustafa, Andrew Butterfield, Sandra D. Scherer, Emilio Cortes-Sanchez, Tyler Bodily, Benjamin T. Spike, Bryan E. Welm, Philip S. Bernard, and Thomas A. Zangle. in press at Communications Biology, preprint available at bioRxiv 2021.11.26.467625

FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma
Grace Orstad, Gabriela Fort, Timothy J. Parnell, Alex Jones, Chris Stubben, Brian Lohman, Katherine L. Gillis, Walter Orellana, Rushmeen Tariq, Olaf Klingbeil, Klaus Kaestner, Christopher R. Vakoc, Benjamin T. Spike, and Eric L. Snyder. Developmental Cell 2022 Jul 5;S1534-5807(22)00458-0

Whence CRIPTO: The Reemergence of an Oncofetal Factor in 'Wounds' That Fail to Heal.
David W Freeman, Elisa Rodrigues Sousa, Sofia Karkampouna, Eugenio Zoni, Peter C Gray, David S Salomon, Marianna Kruithof-de Julio, Benjamin T Spike Int J Mol Sci. 2021 Sep 21;22(18):10164.

Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland.
Manish Ranjan, Oukseub Lee, Gannon Cottone, Elnaz Mirzaei Mehrabad, Benjamin T Spike, Zexian Zeng, Shivangi Yadav, Robert Chatterton, J Julie Kim, Susan E Clare, Seema A Khan Breast Cancer Res. 2021 Aug 3;23(1):78.

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma.
Rediet Zewdu, Elnaz Mirzaei Mehrabad, Kelley Ingram, Pengshu Fang, Katherine L Gillis, Soledad A Camolotto, Grace Orstad, Alex Jones, Michelle C Mendoza, Benjamin T Spike, Eric L Snyder. Elife. 2021 Apr 6;10:e66788.

CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress. Ozlen Balcioglu, Richard E. Heinz, David W. Freeman, Brooke L. Gates, Berhane M. Hagos, Evan Booker, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Kishan Bhakta, Supraja Ranganathan, Masami Kachi, Mathias Leblanc, Peter C. Gray, Benjamin T. Spike. Breast Cancer Res. 2020 Nov 13;22(1):125.

Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer. Sophie J Cowman, Daniel G Fuja, Xian-De Liu, Rebecca S Slack Tidwell, Neelima Kandula, Deepika Sirohi, Archana M Agarwal, Lyska L Emerson, Sheryl R Tripp, Jeffrey S Mohlman, Miekan Stonhill, Guillermina Garcia, Christopher J Conley, Adam A Olalde, Timothy Sargis, Adela Ramirez-Torres, Jose A Karam, Christopher G Wood, Kanishka Sircar, Pheroze Tamboli, Kenneth Boucher, Benjamin Maughan, Benjamin T Spike, Thai H Ho, Neeraj Agarwal, Eric Jonasch, Mei Yee Koh. Clin Cancer Res. 2020 Sep 15;26(18):4970-4982.

MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. Abbie S. Ireland, Alexi M Micinski, David W Kastner, Bingqian Guo, Sarah J Wait, Kyle B Spainhower, Christopher C Conley, Opal S Chen, Matthew R Guthrie, Danny Soltero, Yi Qiao, Xiaomeng Huang, Szabolcs Tarapcsák, Siddhartha Devarakonda, Milind D Chalishazar, Jason Gertz, Justin C Moser, Gabor Marth, Sonam Puri, Benjamin L Witt, Benjamin T Spike, Trudy G Oliver. Cancer Cell. 2020 Jul 13; 38(1): 60-78. e12.

Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool. Huanmao Jiao, Zhiping Li, Min Wang, Sanjay Katiyar, Gabriele Di Sante, Mehdi Farshchian, Andrew P. South, Cinzia Cocola, Daniele Colombo, Rolland Reinbold, Ileana Zucchi, Kongming Wu, Ira Tabas, Benjamin T. Spike, Richard G. Pestell. Stem Cell Reports. 2019 Jan 8;12(1):135

Single cell transcriptomes resolve stem cell state changes in early mammary gland development. Rajshekhar R. Giraddi, Richard E. Heinz, Ozlen Balcioglu, Berhane Hagos, Mark Novotny, Christy L. Trejo, Christopher Dravis, Luo Wei Rodewald, Jae Hwang, Chi-Yeh Chung, Chris Fan, Roger Lasken, Katherine T. Varley, Charles M. Perou, Geoffrey M. Wahl and Benjamin T. Spike (2018) Cell Reports 24(6):1653-1666.e7

Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.
Maya Saison-Ridinger, Kathleen E. DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T. Spike, Maxim N. Shokhirev, Christopher Liddle, Ruth T. Yu, Michael Downes, Ronald M. Evans, Alan Saghatelian, Andrew M. Lowy, Geoffrey M. Wahl
PLoS One 12 e0189051 (2017)

LGR5 labels but is not essential for stem cellactivity in the embryonic mammary gland.
Christy L. Trejo, Gidsela Luna, Christopher Dravis, Benjamin T. Spike, and Geoffrey M. Wahl.
LGR5 labels but is not essential for stem cellactivity in the emnbryonic mammary gland. NPJ Breast Cancer—npj Breast Cancer 3, Article number: 16 (2017)

Cell state plasticity, stem cells and the generation of intratumoral heterogeneity.
Geoffrey M. Wahl and Benjamin T. Spike.
NPJ Breast Cancer --Review. npj Breast Cancer 3, Article number: 14 (2017)

Breast cancer stem cells and the move toward high resolution stem cell systems.
Benjamin T. Spike.
Chapter 5 in Cancer Stem Cells. ed. by H.Liu and J. Lathia. (Elsevier, 2016). ISBN: 978-0-12-803892-5

Sox10 regulates stem/progenitor and mesenchymal states in mammary epithelial cells.
Christopher Dravis, Benjamin T. Spike, J. Chuck Harrell, Claire Johns, Christy Trejo, E. Michelle Southard-Smith, Charles M. Perou, and Geoffrey M. Wahl.
Cell Reports. Sep 29;12(12):2035-48. (2015)

Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy.
Adam D. Pfefferle, Benjamin T. Spike, Geoffrey M. Wahl, and Charles M. Perou.
Breast Cancer Res Treat. Jan;149(2):425-37. (2015)

The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.
Malgorzata Klausinska, Nadia P. Castro, Maria Cristina Rangel, Benjamin T. Spike, Peter C. Gray, Daniel Bertollette, Frank Cuttitta, and David Salomon.
Seminars in Cancer Biology. Dec;29:51-8. Review. (2014)

Characterization of mammary gland development in MMTV-Cre mediated GRP94 and GRP78 knockout mouse models.
Genyuan Zhu, Miao Wang, Benjamin T. Spike, Peter C. Gray, Jieli Shen, Sung-Hyung Lee, Si-Yi Chen, and Amy S. Lee.
Scientific Reports Jun 23;4:5390 (2014)

Cripto/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.
Benjamin T. Spike, Jonathan A. Kelber, Evan Booker, Madhuri Kalathur, Rose Rodewald, Julia Lipianskaya, Justin La, Marielle He, Tracy Wright, Richard Klemke, Geoffrey M. Wahl and Peter C. Gray.
Stem Cell Reports. Apr 8;2(4):427-439 (COVER PICTURE) (2014)

Transcriptomic Classification of Genetically Engineered Mouse Models of Breast Carcinoma Identifies Human Subtype Counterparts.
Adam D. Pfefferle, Jason I. Herschkowitz, Jerry Usary, J. Chuck Harrell, Benjamin T. Spike, Geoffrey M. Wahl, Jeffrey M. Rosen, and Charles M. Perou.
Genome Biology 2013 Nov 12;14(11):R125 (2013)

Stem cells and the developing mammary gland.
Maisam Makarem, Benjamin T. Spike, Christopher Dravis, Nagarajan Kannan, Geoffrey M. Wahl, and Connie J. Eaves.
Journal of Mammary Gland Biology and Neoplasia. Jun;18(2):209-19 (2013)


A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
Benjamin T. Spike, Dannielle D. Engle, Jennifer C. Lin, Justin La, Samantha K. Cheung and Geoffrey M. Wahl.
Cell Stem Cell Feb 3;10(2):183-97 (2012)

p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.
Benjamin T. Spike and Geoffrey M. Wahl.
Genes and Cancer Apr; 2(4):404-19. (COVER PICTURE) (2011)

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.
Hideaki Mizuno, Benjamin T. Spike, Geoffrey M. Wahl, and Arnold J. Levine.
Proc Natl Acad Sci USA. Dec 28;107(52):22745-50. (2010)

Elevated Poly-(ADP-Ribose)-Polymerase Activity Sensitizes Retinoblastoma-Deficient Cells to DNA Damage-Induced Necrosis.
Huiping Liu, James R. Knabb, Benjamin T. Spike and Kay F. Macleod.
Mol Cancer Res. Jul;7(7):1099-109. (2009)

Deregulated E2f-2 underlies cell cycle and maturation defects in Rb null erythroblasts.
Alexandra Dirlam, Benjamin T. Spike, Kay F. Macleod.
Mol Cell Biol. Dec;27(24):8713-28 (2007)

Thesis (Ph.D.): Benjamin T. Spike, The Retinoblastoma Tumor Suppressor in Stress Erythropoiesis.
(Chicago: University of Chicago Press, Aug. 2007)

Effects of Hypoxia on Heterotypic Macrophage Interactions.
Benjamin T. Spike and Kay F. Macleod
Cell Cycle 6(21): 2620-2624 (2007)

BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.
Kristin Tracy, Benjamin C. Dibling, Benjamin T. Spike, James R. Knabb, Paul Schumacker, and Kay F. Macleod.
Mol Cell Biol. 27(17):6229-42. (2007)

Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse.
Benjamin T. Spike, Benjamin C. Dibling, and Kay F. Macleod.
Blood 110(6):2173-81. (2007)

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.
Abhinav Diwan, Andrew G. Koesters, Amy M. Odley, Suvarnamala Pushkaran, Christopher P. Baines, Benjamin T. Spike, Diedre Daria, Anil G. Jegga, Hartmut Geiger, Bruce J. Aronow, Jeffery D. Molkentin, Kay F. Macleod, Theodosia A. Kalfa, and Gerald W. Dorn, II.
Proc Natl Acad Sci USA. 104(16):6794-9. (2007)

The Rb Tumor suppressor in stress responses and hematopoietic homeostasis.
Benjamin T. Spike and Kay F. Macleod.
Cell Cycle. 4(1):42-45 (2005)

The Rb tumor suppressor is required for stress erythropoiesis.
Benjamin T. Spike, Alexandra Dirlam, Benjamin C. Dibling, James Marvin, Bart O. Williams, Tyler Jacks and Kay F Macleod.
The EMBO Journal 23(21):4319-29 (2004)

New roles for the RB tumor suppressor protein.
Huiping Liu, Benjamin Dibling, Benjamin Spike, Alexandra Dirlam and Kay Macleod.
Current Opinion in Genetics & Development 14(1):55-64 (2004)

Oligoclonal IgA response in the vascular wall in acute Kawasaki Disease.
Anne H. Rowley, Benjamin T. Spike, Carrie A. Mask, Stanford T. Shulman and Susan C. Baker.
Journal of Immunology 166(2):1334-1343 (2001)

Nested quantitative real time PCR for detection of occult tumor cells.
Nicole Max, Karin Wolf, Benjamin Spike, Eckhard Theil and Ulrich Keilholz.
Recent Results in Cancer Research 158: 25-31 (2001)

Book Chapter: Ulrich Keilholz, Nicole Max, Benjamin Spike and Martina Willhauk.
PCR-based detection of malignant cells: Towards molecular staging?
Strategies in Adjuvant Therapy. ed. John M. Kirkwood, (London, 2000; Martin Dunitz Ltd.) Chapter 1 pp.1-18.

Thesis (M.S.): Benjamin T. Spike
Characterization of the DNA damage response in embryonic stem cells.
(San Diego: University of California, San Diego, 1999)

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage.
Mirit I. Aladjem, Benjamin T. Spike, Luo Wei Rodewald, Thomas J. Hope, Martina Klemm, Rudolf Jaenisch and Geoffrey M. Wahl.
Current Biology 8: 145-155. (COVER PICTURE) (1998)