View all Graves BJ publications in NIH PubMed.
Selected Publications
Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors.
Currie SL, Warner SL, Vankayalapati H, Liu X, Sharma S, Bearss DJ, Graves BJ.
SLAS Discovery (2019) 24:77-85
Electrostatic Repulsion Causes Anticooperative DNA Binding between Tumor Suppressor ETS transcription factors and JUN-FOS at Composite DNA Sites.
Madison BJ, Clark KA, Bhachech N, Hollenhorst PC, Graves BJ, Currie SL.
J Biol Chem. (2018) 48:18624-18635
ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.
Currie SL, Doane JJ, Evans KS, Bhachech N, Madison BJ, Lau DKW, McIntosh LP, Skalicky JJ, Clark KA, Graves BJ. J Mol Biol. (2017) 429:2975-2995
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Currie SL, Lau DKW, Doane JJ, Whitby FG, Okon M, McIntosh LP, Graves BJ. Nucleic Acids Res. (2017) 45:2223-2241
Conformational Dynamics and the Binding of Specific and Nonspecific DNA by the Autoinhibited Transcription Factor Ets-1.
Desjardins G, Okon M, Graves BJ, McIntosh LP. Biochemistry (2016) 55:4105-18
Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix.
De S, Okon M, Graves BJ, McIntosh LP. J Mol Biol. (2016) 428:1515-30.
Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of Ets-1.
Desjardins G, Meeker CA, Bhachech N, Currie, SL, Graves BJ, McIntosh LP. Proc Natl Acad Sci USA (2014) 111:11019-24
Dual views of SRF: a genomic exposure.
Clark KA, Graves BJ. Genes Dev. (2014) 28:926-8.
Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6.
De S, Chan AC, Coyne HJ 3rd, Bhachech N, Hermsdorf U, Okon M, Murphy ME, Graves BJ, McIntosh LP. J Mol Biol. (2014) 427:1390-406.
Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain.
Coyne HJ 3rd, De S, Okon M, Green SM, Bhachech N, Graves BJ, McIntosh LP. J Mol Biol. (2012) 421:67-84.
Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1.
Ramirez K, Chandler KJ, Spaulding C, Zandi S, Sigvardsson M, Graves BJ, Kee BL. Immunity (2012) 36:921-32.
Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.
Hollenhorst PC, Ferris MW, Hull MA, Chae H, Kim S, Graves BJ. Genes Dev. (2011) 25:2147-57.
Genomic and biochemical insights into the specificity of ETS transcription factors.
Hollenhorst PC, McIntosh LP, Graves BJ. Annu Rev Biochem. (2011) 80:437-71. Review.
The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells.
Hollenhorst PC, Paul L, Ferris MW, Graves BJ. Genes Cancer. (2011) 1:1044-1052.
ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.
Thyagarajan B, Blaszczak AG, Chandler KJ, Watts JL, Johnson WE, Graves BJ. PLoS Genet. (2010) 6:e1001125.
DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association.
Green SM, Coyne HJ 3rd, McIntosh LP, Graves BJ. J Biol Chem. (2010) 285:18496-504.
Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.
Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ. Proc Natl Acad Sci USA. (2010) 107:10026-31.
Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.
Oler AJ, Alla RK, Roberts DN, Wong A, Hollenhorst PC, Chandler KJ, Cassiday PA, Nelson CA, Hagedorn CH, Graves BJ, Cairns BR. Nat Struct Mol Biol. (2010) 17:620-8.
The GNUMAP algorithm: unbiased probabilistic mapping of oligonucleotides from next-generation sequencing.
Clement NL, Snell Q, Clement MJ, Hollenhorst PC, Purwar J, Graves BJ, Cairns BR, Johnson WE. Bioinformatics. (2010) 26:38-45.
DNA specificity determinants associate with distinct transcription factor functions.
Hollenhorst PC, Chandler KJ, Poulsen RL, Johnson WE, Speck NA, Graves BJ. PLoS Genet. (2009) 5:e1000778.
Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.
Hollenhorst PC, Shah AA, Hopkins C, Graves BJ. Genes Dev. (2007) 21:1882-94.
Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.
Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, McIntosh LP, Graves BJ. Science. (2005) 309:142-5.
The structural and dynamic basis of Ets-1 DNA binding autoinhibition.
Lee GM, Donaldson LW, Pufall MA, Kang HS, Pot I, Graves BJ, McIntosh LP. J Biol Chem. (2005) 280:7088-99.
Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.
Foulds CE, Nelson ML, Blaszczak AG, Graves BJ. Mol Cell Biol. (2004) 24:10954-64.
Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors.
Hollenhorst PC, Jones DA, Graves BJ. Nucleic Acids Res. (2004) 32:5693-702.
Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships.
Garvie CW, Pufall MA, Graves BJ, Wolberger C. J Biol Chem. (2002) 277:45529-36.
Autoinhibitory domains: modular effectors of cellular regulation.
Pufall MA, Graves BJ. Annu Rev Cell Dev Biol. (2002) 18:421-62. Review.
An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.
Seidel JJ, Graves BJ. Genes Dev. (2002) 16:127-37.
Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition.
Cowley DO, Graves BJ. Genes Dev. (2000) 14:366-76.
Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1).
Gu TL, Goetz TL, Graves BJ, Speck NA. Mol Cell Biol. (2000) Jan;20(1):91-103.
Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.
Goetz TL, Gu TL, Speck NA, Graves BJ. Mol Cell Biol. (2000) 20:81-90.
Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site.
Slupsky CM, Gentile LN, Donaldson LW, Mackereth CD, Seidel JJ, Graves BJ, McIntosh LP. Proc Natl Acad Sci USA. (1998) 95:12129-34.
Specificity within the ets family of transcription factors.
Graves BJ, Petersen JM. Adv Cancer Res. (1998) 75:1-55. Review.
Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix.
Petersen JM, Skalicky JJ, Donaldson LW, McIntosh LP, Alber T, Graves BJ. Science. (1995) 269:1866-9.
Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif.
Nye JA, Petersen JM, Gunther CV, Jonsen MD, Graves BJ. Genes Dev. (1992) 6:975-90.
Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.
Gunther CV, Nye JA, Bryner RS, Graves BJ. Genes Dev. (1990) 4:667-79.