Academics & Research

Cardiovascular Research & Training Institute Labs


  • Chaudhuri lab

    The Chaudhuri lab studies mitochondrial calcium signaling and intracellular ion channels. A main goal is to define how heart failure alters mitochondrial calcium signalling, since calcium is a potent stimulator of ATP synthesis. A second goal is to study intracellular ion channels, utilizing our extensive experience in subcellular electrophysiological analysis.

    Dipayan Chaudhuri Bio

  • Dosdall Lab

    The Dosdall lab utilizes cardiac mapping techniques to investigate the onset, maintenance, and treatments for cardiac arrhythmias. Specific areas of emphasis include understanding the mechanisms of irregular arrhythmias such as atrial and ventricular fibrillation and developing improved translational therapies for avoiding and terminating them

    Derek Dosdall Bio

  • Drakos Lab

    The Drakos Lab studies myocardial recovery in the chronic heart failure (HF) setting and the acute setting (i.e. acute HF/cardiogenic shock). Several ongoing research projects are focused on understanding the clinical, metabolic and molecular profile of the failing and recovered heart and utilize biological information derived from studies in humans, small and large animal HF models to help understand, predict and manipulate myocardial recovery.

    Stavros Drakos Bio

  • Franklin Lab

    The Franklin lab studies how the packaging of DNA around nucleosomes influences specific patterns of gene expression and how this packaging is modulated during disease to alter transcriptional activity. Their research aims to understand the mechanistic basis for how remodeling of chromatin induces the re-expression of fetal genes in the heart during the development of hypertrophy and failure.

    Sarah Franklin Bio

  • Junco Warren Lab

    Dr. Warren’s research focuses on understanding the mechanisms involved in metabolic remodeling and cardiac energy deficits in the diseased and stressed heart. Her research over the last few years has used a multi-platform metabolomics approach, which provides a systems view of metabolic profile of diseased hearts.

    Junco Warren Bio

  • MacLeod Lab

    The MacLeod lab studies electrocardiographic mapping of the heart and body surface. Specific research areas includes cardiac electrophysiology in the study of acute ischemia and repolarization abnormalities; and computational electrophysiology in solving electrocardiographic forward and inverse problems.

    Robert S. MacLeod Bio

  • Mark Warren Lab

    The Mark Warren lab focuses on understanding the mechanisms involved in the initiation and perpetuation of atrial and ventricular fibrillation. Our lab uses fluorescent probes in combination with optical mapping techniques to investigate the macroscopic organization of fibrillation using whole heart preparations.

    Mark Warren Bio

  • Ranjan Lab

    The Ranjan lab studies the pathogenesis of cardiac arrhythmias like atrial fibrillation. The research involves using non-invasive imaging like MRI to quantify the structural changes in the atrial myocardium and study its clinical implications. The lab is also keenly interested in developing an imaging modality to confirm the delivery of ablation lesions in real-time in the myocardial tissue.

    Ravi Ranjan Bio

  • Sachse Lab

    The Sachse lab studies cardiac electro-mechanics. This includes examining the biophysical modeling of ion channels, cells, and tissue; and confocal imaging.

    Frank Sachse Bio

  • Selzman Lab

    Craig Selzman Bio

  • Tristani-Firouzi Lab

    The Tristani-Firouzi lab studies the structural basis of K+ channel function and the cellular mechanisms that underlie susceptibility to arrhythmia. Specifically, the lab is focused on understanding how voltage-gated K+ channels “sense” the surrounding membrane potential and the mechanism(s) through which voltage-sensing is coupled to channel opening and inactivation.

    Martin Tristani-Firouzi Bio