Neon Fish for Curing Cancer: Tall section of a fixed and stained zebrafish larva. Green marks the plasma membranes of the top layer of skin cells; red, the nuclei of the bottom layer of skin cells; and blue, the nuclei of all cells in the fish. Where the read and blue coincide, we see magenta! In addition, there are two adjacent, bright green cell masses in hte upper middle part of the image. These are tumor cells that harbor a mutant form of an oncogene that causes many human cancers. We use the zebrafish as a model to ask how these tumor cells invade during metastasis, and how we could "drug" this pathway to prevent
Mirror Cells: In this mirror image presentation of fibroblast cells, adhesion sites at the cell edge contain zyxin protein (Red), and the center of the cell contains intranuclear DNA (DAPI, Blue), and intranuclear Lamin A/C protein (Green).
Elephant TP53 in Hek293 Cells: Interestingly, elephants don't get cancer! The Schiffman Lab studies a tumor suppressor gene called TP53 because elephants have extra copies of TP53 that prevent elephants from getting cancer. This research goes from the lab to the clinic by trying to use the elephant protein to treat and prevent cancer in humans. This is an image of human kidney cells that have the elephant protein inside them. We can visualize where the protein is present in the cell because it is labelled with green florescent protein (GFP). Additionally, each cell's nucleus is stained so it glows blue. These cells can then be used in many different experiments to see how they are functioning.
Advancing Medicine & Science
The Senior Vice President for Health Sciences Research Unit serves the University of Utah Health Sciences community in pursuit of discovery and innovation that advances medicine and science. The office seeks to strengthen all departments and colleges within the University of Utah Health Sciences by assisting in:
- Research Strategic Planning,
- Decision support,
- Goal setting,
- Administrative and Programmatic Expertise,
- Program development
The research unit’s major functions include institutional goal setting, oversight of graduate programs, the summer medical research program, training grant proposal support, financial modeling, pre-award support for basic science departments, research space management, new program development, and execution of the Health Sciences’ Research Strategic Initiatives.