PRR - Patient-Derived Xenograft Repository

Patient derived xenografts (PDX) are samples grafted directly from a patient into an immunodeficient mouse. Under these conditions, the tumor continues to grow and metastasize, allowing propagation of the human cancer.

The PRR maintains and distributes viable crypopreserved tumor tissue, organoids, and unstained FFPE tumor sections associated with all common subtypes of breast cancer. Publications have shown that the breast PDX models maintain similar molecular profiles to the parent tumor, meaning these tumor grafts create an excellent model to test new chemotherapies and drug delivery systems in a preclinical setting.

We can help you use these tumor models to test your small molecule, including implantation of tumor tissue, tumor growth monitoring, drug dosing, and necropsy.

For more information on these models, please see these publications:

• A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
• Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
• Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine